Godts P
Arzneimittelforschung. 1987 May;37(5):577-9.
44 patients with candidal vaginitis participated in a trial using a new formulation of a mepartricin-sodium lauryl sulfate complex for local administration (dosage schedule: one 25,000-unit vaginal tablet (SPA-S-222) daily for 6 days). Microbiological examination revealed an 88.6% cure rate (samples tested negative) at the end of treatment and a 90.9% cure rate 30 days after cessation of treatment. In addition, the clinical symptoms observed at the beginning of treatment disappeared rapidly and the patients showed great clinical improvement under the present therapy. Both local and systemic tolerance of the preparation used were excellent.
44例念珠菌性阴道炎患者参与了一项试验，使用一种新配方的甲帕霉素-十二烷基硫酸钠复合物进行局部给药（给药方案：每日1片25000单位的阴道片（SPA-S-222），共6天）。微生物学检查显示，治疗结束时治愈率为88.6%（样本检测为阴性），停药30天后治愈率为90.9%。此外，治疗开始时观察到的临床症状迅速消失，患者在当前治疗下临床症状有显著改善。所用制剂的局部和全身耐受性均良好。
