Cetinkaya Feyza Izci, Mumcu Necati, Unuvar Gamze Kalin, Kilic Aysegul Ulu, Kaynar Leylagul
Department of Infectious Diseases, Erciyes University Faculty of Medicine, Kayseri, Turkiye.
Department of Hematology, Erciyes University Faculty of Medicine, Kayseri, Turkiye.
North Clin Istanb. 2022 May 11;9(3):282-285. doi: 10.14744/nci.2020.66049. eCollection 2022.
Cerebral toxoplasmosis is a rare but often life-threatening infection after hematopoietic stem cell transplantation (HSCT). In such cases, early diagnosis and initiation of treatment are vital. We describe a case of cerebral toxoplasmosis in a patient who underwent HSCT for acute myeloid leukemia. Infection was diagnosed with polymerase chain reaction (PCR) test of cerebrospinal fluid and cranial magnetic resonance imaging scan. The patient treated with trimethoprim-sulfamethoxazole and clindamycin combination. However, she died from nosocomial infection after 15 days of treatment. This life-threatening infection should be considered in a patient who is post-HSCT present with neurologic symptoms and brain lesions. PCR is an important and rapid diagnostic tool for toxoplasmosis. Cranial imaging scan and PCR should be used together to diagnosed.
脑弓形虫病是造血干细胞移植（HSCT）后一种罕见但常危及生命的感染。在这类病例中，早期诊断和开始治疗至关重要。我们描述了一例因急性髓系白血病接受HSCT的患者发生脑弓形虫病的病例。通过脑脊液聚合酶链反应（PCR）检测和头颅磁共振成像扫描诊断出感染。患者接受了甲氧苄啶 - 磺胺甲恶唑和克林霉素联合治疗。然而，她在治疗15天后死于医院感染。对于HSCT后出现神经症状和脑病变的患者，应考虑这种危及生命的感染。PCR是诊断弓形虫病的重要且快速的诊断工具。头颅成像扫描和PCR应联合使用以进行诊断。
