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早发性基底细胞癌;安纳托利亚中部单一三级中心的广泛病例系列研究

Early-onset basal cell carcinoma; wide case series at a single tertiary center in middle Anatolia.

作者信息

Kilinc Ayse Nur Ugur, Bayramoglu Zeynep, Unlu Yasar

机构信息

Department of Pathology, Konya Training and Research Hospital, Konya, Turkiye.

出版信息

North Clin Istanb. 2022 Jul 8;9(3):261-265. doi: 10.14744/nci.2020.78872. eCollection 2022.

DOI:10.14744/nci.2020.78872
PMID:36199869
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9464849/
Abstract

OBJECTIVE

Although basal cell carcinoma (BCC) is prevalent in the older population, it can be rarely seen in younger people. This study aims to investigate the risk factors and characteristics of BCC in young patients.

METHODS

Pathology reports in a single tertiary care institution between 2010 and 2020 were retrospectively reviewed. Patients under the age of 35 who were diagnosed with BCC were included for the analysis. Data were gathered from medical records and pathology reports. Demographic characteristics, accompanying pathologies, and clinical findings of these patients were analyzed.

RESULTS

There were a total of 32 patients in our cohort. Out of 32 patients, 20 were female and 12 were male. One male patient and five female patients were younger than 18. An accompanying risk factor (Gorlin syndrome, XP, renal transplantation, etc.) was present in six patients. There were no known additional diseases or risk factors in 26 patients. Metastasis and recurrence were not reported in any of our patients. Contrary to the information in the literature, the patients with BCC at a young age were not found more aggressive in our study.

CONCLUSION

Contrary to the information in the literature, the patients with BCC at a young age were not found more aggressive in our study. Understanding the risk factors associated with BCC is essential for designing prevention strategies and favoring early diagnosis. Awareness of early-onset BCC aids in early diagnosis and treatment of the disease. Therefore, BCC should be in the differential diagnosis of skin lesions in the young population. In addition, when we encounter early-onset BCC, we should not forget the accompanying risk factors and syndromes.

摘要

目的

尽管基底细胞癌(BCC)在老年人群中很常见,但在年轻人中却很少见。本研究旨在调查年轻患者BCC的危险因素和特征。

方法

回顾性分析2010年至2020年期间一家三级医疗机构的病理报告。纳入35岁以下被诊断为BCC的患者进行分析。数据从病历和病理报告中收集。分析这些患者的人口统计学特征、伴随病变和临床发现。

结果

我们的队列中共有32例患者。32例患者中,20例为女性,12例为男性。1例男性患者和5例女性患者年龄小于18岁。6例患者存在伴随危险因素(戈林综合征、着色性干皮病、肾移植等)。26例患者无已知的其他疾病或危险因素。我们的患者中均未报告转移和复发情况。与文献中的信息相反,在我们的研究中未发现年轻BCC患者更具侵袭性。

结论

与文献中的信息相反,在我们的研究中未发现年轻BCC患者更具侵袭性。了解与BCC相关的危险因素对于设计预防策略和促进早期诊断至关重要。认识早发性BCC有助于疾病的早期诊断和治疗。因此,BCC应纳入年轻人群皮肤病变的鉴别诊断中。此外,当我们遇到早发性BCC时,不应忘记其伴随的危险因素和综合征。

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本文引用的文献

1
Basal Cell Carcinoma in young adults.年轻成年人中的基底细胞癌。
Actas Dermosifiliogr. 2017 May;108(4):376-377. doi: 10.1016/j.ad.2016.10.012. Epub 2016 Dec 5.
2
Postzygotic mosaicism in basal cell naevus syndrome.基底层细胞痣综合征中的合子后镶嵌性。
Br J Dermatol. 2017 Jul;177(1):249-252. doi: 10.1111/bjd.15082. Epub 2017 Jun 6.
3
Distinct Histologic Subtypes and Risk Factors for Early Onset Basal Cell Carcinoma: A Population-Based Case Control Study from New Hampshire.早发性基底细胞癌的不同组织学亚型和危险因素:一项来自新罕布什尔州的基于人群的病例对照研究。
J Invest Dermatol. 2016 Feb;136(2):533-535. doi: 10.1016/j.jid.2015.11.002. Epub 2015 Nov 18.
4
Increasing skin cancer incidence in young, affluent, urban populations: a challenge for prevention.年轻、富裕、城市人口中皮肤癌发病率的上升:预防面临的挑战。
Br J Dermatol. 2014 Aug;171(2):324-31. doi: 10.1111/bjd.12988. Epub 2014 Aug 2.
5
Basal cell carcinoma in childhood: a case report.儿童基底细胞癌:一例报告
Pediatr Dermatol. 2013 Jan-Feb;30(1):144-5. doi: 10.1111/j.1525-1470.2011.01591.x. Epub 2011 Dec 30.
6
Indoor tanning and risk of early-onset basal cell carcinoma.室内晒黑与早期基底细胞癌风险。
J Am Acad Dermatol. 2012 Oct;67(4):552-62. doi: 10.1016/j.jaad.2011.11.940. Epub 2011 Dec 9.
7
Multiple cutaneous malignancies in a patient of xeroderma pigmentosum.一名着色性干皮病患者出现多发性皮肤恶性肿瘤。
J Cancer Res Ther. 2011 Apr-Jun;7(2):205-7. doi: 10.4103/0973-1482.82932.
8
[Frequency of basal cell carcinoma in a population younger than 50 years of age: clinical study and literature review].[50岁以下人群基底细胞癌的发病率:临床研究与文献综述]
An Bras Dermatol. 2009 Nov-Dec;84(6):692-4. doi: 10.1590/s0365-05962009000600021.
9
Pediatric basal cell carcinoma: case reports and literature review.儿童基底细胞癌:病例报告与文献综述
J Pediatr Surg. 2008 Dec;43(12):2277-80. doi: 10.1016/j.jpedsurg.2008.08.035.
10
Epidermolysis bullosa and the risk of life-threatening cancers: the National EB Registry experience, 1986-2006.大疱性表皮松解症与危及生命的癌症风险:1986 - 2006年国家大疱性表皮松解症登记处经验
J Am Acad Dermatol. 2009 Feb;60(2):203-11. doi: 10.1016/j.jaad.2008.09.035. Epub 2008 Nov 20.