Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Curr Stem Cell Res Ther. 2023;18(6):787-799. doi: 10.2174/1574888X17666221004105330.
Breast cancer stem cells (BCSCs) are heterogeneous tumor-initiating cell subgroups of breast cancers that possess some stem cell markers and are sustained after chemotherapy. Due to BCSCs being sufficient for tumor relapse, and given that the biological behaviors of BCSCs are so complex, it is critical to figure out exactly how they work, learn more about their cell biology, and discover biomarkers and strategies for explicitly targeting and destructing cancer stem cells. In order to accomplish innovative treatment for breast cancer, it is also essential to target BCSCs. Despite the vast quantities of BCSC target chemicals, their therapeutic implementation is limited due to off-target behavior and bioavailability issues. Targeted drug delivery systems based on nanoparticles have advantages for transporting anti-BCSC materials, especially to targeted locations. Hence, breast cancer therapy using a nanoparticle-based BCSCs targeting system is a promising strategy. Such targeted drug delivery systems can resolve the biodistribution obstacles of nanosystems. Throughout this paper, we highlight various strategies for targeting BCSCs utilizing nano-based systems. In conclusion, issues about the inadequate stability of nanoparticles and the possibility of loaded drug leakage during delivery systems have yet to be answered. More fundamental and applied research, and proper methods such as coating or surface modification are required.
乳腺癌干细胞（BCSCs）是乳腺癌中具有某些干细胞标志物的异质性肿瘤起始细胞亚群，在化疗后仍能维持。由于 BCSCs 足以引起肿瘤复发，而且 BCSCs 的生物学行为如此复杂，因此必须确切了解它们的工作原理，更多地了解它们的细胞生物学，并发现用于明确靶向和破坏癌症干细胞的生物标志物和策略。为了实现乳腺癌的创新治疗，靶向 BCSCs 也至关重要。尽管有大量针对 BCSC 的靶向化学物质，但由于脱靶行为和生物利用度问题，其治疗应用受到限制。基于纳米颗粒的靶向药物输送系统在输送抗 BCSC 材料方面具有优势，尤其是在靶向部位。因此，使用基于纳米颗粒的 BCSCs 靶向系统进行乳腺癌治疗是一种很有前途的策略。这种靶向药物输送系统可以解决纳米系统的生物分布障碍。在本文中，我们重点介绍了利用纳米系统靶向 BCSCs 的各种策略。总之，关于纳米粒子的稳定性不足以及在输送系统中载药泄漏的可能性等问题尚未得到解答。需要进行更多的基础和应用研究，以及适当的方法，如涂层或表面修饰。
