Gelissen M, Cools A
Behav Brain Res. 1987 Jul;25(1):1-11. doi: 10.1016/0166-4328(87)90040-4.
The present feline study deals with the execution of targeting movements which can be elicited either by injection of picrotoxin into the deeper layers of the superior colliculus (dl-SC) or by application of muscimol into the substantia nigra pars reticulata (SNR), and suppressed either by dl-SC injection of muscimol or by SNR application of picrotoxin: the movements under discussion are the so-called non-externally guided targeting movements, i.e. targeting movements that are elicited but not continuously guided by external (visual, auditory, olfactory and tactile) stimuli. In this study we investigated whether the integrity of the SNR is required for the execution of these targeting movements elicited from the dl-SC. Cats were trained, therefore, to walk from one side of a narrow bar to the other side under stroboscopic illumination (2 flashes/s). The animals received bilateral injections both into the SNR (solvent 0.5 microliter or picrotoxin 500 ng/0.5 microliter) and into the dl-SC (solvent 0.5 microliter or picrotoxin 50-100 ng/0.5 microliter). Injections of picrotoxin into the dl-SC did not evoke non-externally guided targeting movements in case picrotoxin was also injected into the SNR. It is concluded that the integrity of the SNR is required for the execution of non-externally guided targeting movements elicited from the dl-SC. Besides, we investigated whether freezing, i.e., an SNR-specific effect, which can be evoked by injection of picrotoxin into this area, is funnelled through the dl-SC. Therefore, the behaviour of cats which had received bilateral injections both into the SNR (solvent 0.5 microliter or picrotoxin 500 ng/0.5 microliter) and into the dl-SC (solvent 0.5 microliter or picrotoxin 50-100 ng/0.5 microliter) was analysed. Application of picrotoxin into the dl-SC did not suppress the occurrence of freezing, elicited by SNR injection of picrotoxin. It is concluded that the SNR-specific freezing is not channelled through the dl-SC.
当前的猫科动物研究涉及靶向运动的执行，这种运动可通过将印防己毒素注射到上丘深层（dl-SC）或通过将蝇蕈醇应用于黑质网状部（SNR）来诱发，并且可通过向dl-SC注射蝇蕈醇或向SNR应用印防己毒素来抑制：所讨论的运动是所谓的非外部引导靶向运动，即由外部（视觉、听觉、嗅觉和触觉）刺激诱发但不持续引导的靶向运动。在本研究中，我们调查了从dl-SC引发的这些靶向运动的执行是否需要SNR的完整性。因此，训练猫在频闪照明（2次闪光/秒）下从窄杆的一侧走到另一侧。动物接受双侧注射，分别注入SNR（溶剂0.5微升或印防己毒素500纳克/0.5微升）和dl-SC（溶剂0.5微升或印防己毒素50 - 100纳克/0.5微升）。如果也将印防己毒素注入SNR，向dl-SC注射印防己毒素不会诱发非外部引导靶向运动。得出的结论是，从dl-SC引发的非外部引导靶向运动的执行需要SNR的完整性。此外，我们调查了冻结反应，即一种可通过向该区域注射印防己毒素诱发的SNR特异性效应，是否通过dl-SC传导。因此，分析了接受双侧注射到SNR（溶剂0.5微升或印防己毒素500纳克/0.5微升）和dl-SC（溶剂0.5微升或印防己毒素50 - 100纳克/0.5微升）的猫的行为。向dl-SC应用印防己毒素不会抑制由向SNR注射印防己毒素引发的冻结反应的发生。得出的结论是，SNR特异性冻结反应不通过dl-SC传导。
