Pereira Miguel Augusto Martins, Jordan Roger Freitas Ramirez, Matos Jorge Paulo Strogoff de, Carraro-Eduardo José Carlos
Universidade Federal Fluminense, Escola de Medicina, Niterói, RJ, Brazil.
Universidade Federal Fluminense, Escola de Medicina, Departamento de Nefrologia, Niterói, RJ, Brazil.
J Bras Nefrol. 2023 Apr-Jun;45(2):252-256. doi: 10.1590/2175-8239-JBN-2022-0079en.
The albumin-to-creatinine ratio and total protein-to-creatinine ratio in spot urine samples have already been validated as surrogates for 24-hour albuminuria and proteinuria measurements. Thus, we hypothesized that the type of proteinuria, detected by the electrophoretic pattern of 24-hour urine, could be predicted by the simple proportion of albumin in the total urine protein content, using the albumin-to-protein ratio (APR). Our study sought to validate the use of APR as a cheaper substitute for urinary protein electrophoresis (UPE).
Using different mathematical models, we compared, the albumin fraction in 24-hour urine samples by electrophoresis and the APR ratio in spot samples from 42 outpatients with chronic kidney disease (CKD).
A strong log-order correlation r = 0.84 (0.75-0.92; 95% CI, p = 0.001) was observed between APR and the albumin fraction in the UPE.
The APR can substitute electrophoresis in CKD outpatients.
随机尿样中的白蛋白与肌酐比值及总蛋白与肌酐比值已被确认为24小时蛋白尿和白蛋白尿测量的替代指标。因此，我们推测，通过24小时尿液电泳图谱检测的蛋白尿类型，可利用白蛋白与蛋白质比值（APR），即白蛋白在总尿蛋白含量中的简单占比来预测。我们的研究旨在验证APR作为尿蛋白电泳（UPE）更廉价替代方法的实用性。
我们运用不同数学模型，比较了42例慢性肾脏病（CKD）门诊患者24小时尿液样本经电泳得出的白蛋白比例与随机样本中的APR比值。
APR与UPE中的白蛋白比例之间存在强对数顺序相关性，r = 0.84（0.75 - 0.92；95%置信区间，p = 0.001）。
APR可替代CKD门诊患者的电泳检查。
