Chávez-Genaro Rebeca, Toledo Agustina, Hernández Karina, Anesetti Gabriel
Laboratorio de Biología de la Reproducción, Departamento de Histología y Embriología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.
J Mol Histol. 2022 Dec;53(6):903-914. doi: 10.1007/s10735-022-10106-5. Epub 2022 Oct 6.
Fetal or neonatal androgen exposure has a programming effect on ovarian function inducing a polycystic ovarian syndrome-like condition. Its effects on uterine structure and function are poorly studied. The aim of this work was to characterize the temporal course of changes in the rat uterine structure induced by neonatal exposure to aromatizable or not aromatizable androgens. Rats were daily treated with testosterone, dihydrotestosterone or vehicle during follicle assembly period (postnatal days 1 to 5). Uterine histoarchitecture, hormonal milieu, endometrial stromal collagen and capillary density were analyzed at prepubertal, pubertal and adult ages. Our data shows that neonatal androgen exposure induces early and long-lasting deleterious effects on uterine development, including altered adenogenesis and superficial epithelial alterations and suggest a role for altered serum estradiol levels in the maintenance and worsening of the situation. Our results suggest that alterations of the neonatal androgenic environment on the uterus could be responsible for alterations in the processes of implantation and maintenance of the embryo in women with polycystic ovary syndrome.
胎儿期或新生儿期雄激素暴露对卵巢功能具有编程效应，可诱发多囊卵巢综合征样病症。其对子宫结构和功能的影响研究较少。本研究的目的是描述新生大鼠暴露于可芳香化或不可芳香化雄激素后子宫结构变化的时间进程。在卵泡组装期（出生后第1至5天），每天给大鼠注射睾酮、双氢睾酮或赋形剂。在青春期前、青春期和成年期分析子宫组织结构、激素环境、子宫内膜基质胶原蛋白和毛细血管密度。我们的数据表明，新生儿期雄激素暴露对子宫发育具有早期和长期的有害影响，包括腺生成改变和表面上皮改变，并提示血清雌二醇水平改变在维持和恶化这种情况中起作用。我们的结果表明，多囊卵巢综合征女性新生儿雄激素环境的改变可能是胚胎着床和维持过程改变的原因。
