Switzer Christopher H, Fukuto Jon M
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Department of Chemistry, Johns Hopkins University, Baltimore, MD, 21218, USA; Department of Chemistry, Sonoma State University, Rohnert Park, CA, 94928, USA.
Redox Biol. 2022 Nov;57:102486. doi: 10.1016/j.redox.2022.102486. Epub 2022 Sep 25.
It has become apparent that hydrogen sulfide (HS), hydropersulfides (RSSH) and other polysulfide species are all intimately linked biochemically. Indeed, at least some of the biological activity attributed to hydrogen sulfide (HS) may actually be due to its conversion to RSSH and derived polysulfur species (and vice-versa). The unique chemistry associated with the hydropersulfide functional group (-SSH) predicts that it possesses possible protective properties that can help a cell contend with oxidative and/or electrophilic stress. However, since RSSH and polysulfides possess chemical properties akin to disulfides (RSSR), they can also be sources of oxidative/electrophilic stress/signaling as well. Herein are discussed the unique chemistry, possible biochemistry and the physiological implications of RSSH (and polysulfides), especially as it pertains to their putative cellular protection properties against a variety of stresses and/or as possible stressors/signaling agents themselves.
显而易见，硫化氢（HS）、氢多硫化物（RSSH）以及其他多硫化物在生化方面都紧密相连。实际上，至少某些归因于硫化氢（HS）的生物活性可能实际上是由于其转化为RSSH和衍生的多硫物种（反之亦然）。与氢多硫化物官能团（-SSH）相关的独特化学性质预示着它具有可能的保护特性，能够帮助细胞应对氧化和/或亲电应激。然而，由于RSSH和多硫化物具有类似于二硫化物（RSSR）的化学性质，它们也可能是氧化/亲电应激/信号传导的来源。本文将讨论RSSH（和多硫化物）的独特化学性质、可能的生物化学以及生理意义，特别是涉及其针对各种应激的假定细胞保护特性，或者它们本身作为可能的应激源/信号传导剂的情况。
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