Rasooly Danielle, Yang Quanhe, Moonesinghe Ramal, Khoury Muin J, Patel Chirag J
Office of Genomics and Precision Public Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Division for Heart Disease and Stroke Prevention, NCCDPHP, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Public Health Genomics. 2022 Oct 6:1-12. doi: 10.1159/000526242.
Family history is an established risk factor for both cardiovascular disease (CVD) and diabetes; however, no study has presented population-based prevalence estimates of family histories of CVD and diabetes and examined their joint impact on prevalence of diabetes, CVD, cardiometabolic risk factors, and mortality risk.
We analyzed data from a representative sample of the US adult population including 29,440 participants from the National Health and Nutrition Examination Survey (2007-2018) and assessed self-reported first-degree family history of diabetes and CVD (premature heart disease before age of 50 years) as well as meeting criteria and/or having risk factors for CVD and diabetes.
Participants with joint family history exhibit 6.5 greater odds for having both diseases and are diagnosed with diabetes 6.6 years earlier than participants without family history. Healthy participants without prevalent CVD or diabetes but with joint family history exhibit a greater prevalence of diabetes risk factors compared to no family history counterparts. Joint family history is associated with an increase in all-cause mortality, but with no interactive effect.
Over 44% of the US adult population has a family history of CVD and/or diabetes that is comparable in risk to common cardiometabolic risk factors. This wide presence of high-risk family history and its simplicity of ascertainment suggests that clinical and public health efforts should collect and act on joint family history of CVD and diabetes to improve population efforts in the prevention and early detection of these common chronic diseases.
家族病史是心血管疾病（CVD）和糖尿病公认的风险因素；然而，尚无研究给出基于人群的CVD和糖尿病家族病史患病率估计值，也未考察它们对糖尿病患病率、CVD、心脏代谢危险因素及死亡风险的联合影响。
我们分析了来自美国成年人群代表性样本的数据，其中包括来自国家健康与营养检查调查（2007 - 2018年）的29440名参与者，并评估了自我报告的糖尿病和CVD一级家族病史（50岁前的早发性心脏病），以及符合CVD和糖尿病标准及/或有相关危险因素的情况。
有联合家族病史的参与者患这两种疾病的几率比无家族病史的参与者高6.5倍，且被诊断出糖尿病的时间比无家族病史者早6.6年。没有普遍存在的CVD或糖尿病但有联合家族病史的健康参与者，与无家族病史的参与者相比，糖尿病危险因素的患病率更高。联合家族病史与全因死亡率增加相关，但无交互作用。
超过44%的美国成年人群有CVD和/或糖尿病家族病史，其风险与常见的心脏代谢危险因素相当。这种高风险家族病史的广泛存在及其确定的简易性表明，临床和公共卫生工作应收集CVD和糖尿病联合家族病史并据此采取行动，以加强人群对这些常见慢性病的预防和早期检测工作。
