Department of Environmental Health, School of Public Health, China Medical University, PR China.
Department of Cardiology, The Second Hospital of Dalian Medical University, Dalian, Liaoning, PR China.
Neuroscience. 2022 Nov 10;504:79-92. doi: 10.1016/j.neuroscience.2022.09.021. Epub 2022 Oct 3.
Sirtuin 1 (SIRT1) is an NAD dependent deacetylase that modify the gene expression through histone deacetylation. SIRT1 plays a crucial role in regulating a wide range of physiological processes by adjustment multiple mechanisms through the deacetylation of multiple substrates. Neurodegenerative diseases are a series of chronic diseases characterized by dysfunction and loss of neurons. Its basic pathogenesis is filamentous tangles and amyloid deposits, such as Amyloid-β (Aβ), tau protein, α-synuclein, including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD). This summarizes introduces the structure and function of SIRT1, and then analyzes the protective effects of SIRT1 on neurological diseases by regulating circadian rhythm, aging, oxidative stress, mitochondrial dysfunction and neuroinflammation related pathways.
Sirtuin 1（SIRT1）是一种 NAD 依赖性去乙酰化酶，通过组蛋白去乙酰化来修饰基因表达。SIRT1 通过对多种底物的去乙酰化作用，通过多种机制的调节，在调节广泛的生理过程中起着至关重要的作用。神经退行性疾病是一系列以神经元功能障碍和丧失为特征的慢性疾病。其基本发病机制是丝状缠结和淀粉样沉积，如淀粉样β（Aβ）、tau 蛋白、α-突触核蛋白，包括阿尔茨海默病（AD）、帕金森病（PD）和亨廷顿病（HD）。本综述介绍了 SIRT1 的结构和功能，然后分析了 SIRT1 通过调节昼夜节律、衰老、氧化应激、线粒体功能障碍和神经炎症相关途径对神经疾病的保护作用。
