Jiao Fangzhou, Gong Zuojiong
Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, 430060 Hubei, China.
Oxid Med Cell Longev. 2020 Sep 14;2020:6782872. doi: 10.1155/2020/6782872. eCollection 2020.
Sirtuins are the class III of histone deacetylases whose deacetylate of histones is dependent on nicotinamide adenine dinucleotide (NAD+). Among seven sirtuins, SIRT1 plays a critical role in modulating a wide range of physiological processes, including apoptosis, DNA repair, inflammatory response, metabolism, cancer, and stress. Neuroinflammation is associated with many neurological diseases, including ischemic stroke, bacterial infections, traumatic brain injury, Alzheimer's disease (AD), and Parkinson's disease (PD). Recently, numerous studies indicate the protective effects of SIRT1 in neuroinflammation-related diseases. Here, we review the latest progress regarding the anti-inflammatory and neuroprotective effects of SIRT1. First, we introduce the structure, catalytic mechanism, and functions of SIRT1. Next, we discuss the molecular mechanisms of SIRT1 in the regulation of neuroinflammation. Finally, we analyze the mechanisms and effects of SIRT1 in several common neuroinflammation-associated diseases, such as cerebral ischemia, traumatic brain injury, spinal cord injury, AD, and PD. Taken together, this information implies that SIRT1 may serve as a promising therapeutic target for the treatment of neuroinflammation-associated disorders.
沉默调节蛋白是Ⅲ类组蛋白去乙酰化酶，其对组蛋白的去乙酰化作用依赖于烟酰胺腺嘌呤二核苷酸（NAD+）。在七种沉默调节蛋白中，SIRT1在调节多种生理过程中起关键作用，包括细胞凋亡、DNA修复、炎症反应、代谢、癌症和应激。神经炎症与许多神经系统疾病相关，包括缺血性中风、细菌感染、创伤性脑损伤、阿尔茨海默病（AD）和帕金森病（PD）。最近，大量研究表明SIRT1在神经炎症相关疾病中具有保护作用。在此，我们综述了关于SIRT1抗炎和神经保护作用的最新进展。首先，我们介绍SIRT1的结构、催化机制和功能。接下来，我们讨论SIRT1调节神经炎症的分子机制。最后，我们分析SIRT1在几种常见的神经炎症相关疾病中的机制和作用，如脑缺血、创伤性脑损伤、脊髓损伤、AD和PD。综上所述，这些信息表明SIRT1可能是治疗神经炎症相关疾病的一个有前景的治疗靶点。
