Antonazzo Ippazio Cosimo, Conti Sara, Rozza Davide, Fornari Carla, Eteve-Pitsaer Caroline, Paris Claire, Gantzer Laurène, Valentine Dennis, Mantovani Lorenzo Giovanni, Mazzaglia Giampiero
Research Centre on Public Health (CESP), University of Milano-Bicocca, Monza, Italy.
Cegedim, Boulogne-Billancourt, France.
Front Neurol. 2022 Sep 20;13:987618. doi: 10.3389/fneur.2022.987618. eCollection 2022.
Although essential tremor (ET) is considered a common adult movement disorder, evidence on its incidence is still scant. This study aims at estimating ET incidence in two European countries, namely, the UK and France.
Incident cases of ET were identified within the Health Improvement Network (THIN®) database between 1st January 2014 and 31 December 2019. Yearly crude and standardized incidence rates (IR) were estimated across the study period for both countries. Poisson regression models were built to assess temporal trends in IRs and differences between sexes and age classes.
In total, 4,970 and 4,905 incident cases of ET were identified in the UK and France, respectively. The yearly average crude IR (per 100,000 person-years) was 18.20 (95%CI: 15.09-21.32) in UK and 21.42 (17.83-25.00) in France, whereas standardized ones were 19.51 (18.97-20.01) and 19.50 (18.97-20.05). Regression analyses showed slightly increasing trends in both countries, higher incidence among males, and a significant increase with age. Yearly average IR increased from 3.96 (0.95-6.97) and 5.28 (1.12-9.44) in subjects aged <20 years to 49.27 (26.29-72.24) and 51.52 (30.19-72.86) in those aged >80 year in UK and France.
Standardized ET incidence was comparable in the UK and France, showing a slight increase in both countries, reporting a higher value among people aged 60 years and older. This study outlines the need to conduct future studies to estimate the burden of ET in terms of disease control and healthcare resource utilization.
尽管特发性震颤（ET）被认为是一种常见的成人运动障碍，但其发病率的证据仍然很少。本研究旨在估计两个欧洲国家，即英国和法国的ET发病率。
在2014年1月1日至2019年12月31日期间，在健康改善网络（THIN®）数据库中识别出ET的发病病例。估计了这两个国家在研究期间的年度粗发病率和标准化发病率（IR）。建立泊松回归模型以评估发病率的时间趋势以及性别和年龄组之间的差异。
在英国和法国分别总共识别出4970例和4905例ET发病病例。英国的年度平均粗发病率（每10万人年）为18.20（95%CI：15.09 - 21.32），法国为21.42（17.83 - 25.00），而标准化发病率分别为19.51（18.97 - 20.01）和19.50（18.97 - 20.05）。回归分析显示两国发病率均呈轻微上升趋势，男性发病率更高，且随年龄显著增加。在英国和法国，年龄<20岁的受试者的年度平均发病率分别从3.96（0.95 - 6.97）和5.28（1.12 - 9.44）增加到年龄>80岁者的49.27（26.29 - 72.24）和51.52（30.19 - 72.86）。
英国和法国的标准化ET发病率相当，两国均呈轻微上升趋势，60岁及以上人群的发病率更高。本研究概述了未来开展研究以估计ET在疾病控制和医疗资源利用方面负担的必要性。
