Baran Caner, Küçükcan Akif
Department of Urology, Çukurova State Hospital, Adana, Turkey.
Department of Microbiology, Çukurova State Hospital, Adana, Turkey.
Curr Urol. 2022 Sep;16(3):180-184. doi: 10.1097/CU9.0000000000000144. Epub 2022 Aug 27.
Pathogen spectrum and antibiotic susceptibility patterns vary in different regions and should consider the empirical treatment of urinary tract infections (UTIs). Information on susceptibility is the basis for providing reliable treatment. This study aimed to determine the antibiotic susceptibility of bacteria isolated from urine cultures at Çukurova State Hospital, which is located south of Turkey and east of the Mediterranean region.
Urine culture results were retrospectively evaluated between April 2018 and January 2021. Variables, such as age, sex, and medical department, were also recorded. Inclusion criteria were patients aged at least 18 years with pathogenic bacterial growth in their urine cultures. Antibiotic susceptibility testing and bacterial identification were performed using the VITEK 2 automated system.
Of 12,288 urine samples, 2033 (16.5%) had pathogenic growth. The rates of bacterial and yeast growth were 93.3% and 6.7%, respectively. Gram-negative pathogens constituted 91.6% of the cohort. The most prevalent bacteria were with a 66% rate, followed by (14.2%). According to our results, ciprofloxacin, trimethoprim-sulfamethoxazole, and ampicillin are not suitable for empirical treatment of UTIs, whereas nitrofurantoin and fosfomycin are rational options.
Uropathogens exhibit an increased resistance rate against ampicillin, trimethoprim-sulfamethoxazole, and ciprofloxacin. Nitrofurantoin, fosfomycin, and ceftazidime have better efficacy than other investigated antibiotics in urine culture against common uropathogens and are suitable for empirical treatment of UTI.
不同地区的病原体谱和抗生素敏感性模式存在差异，这在考虑尿路感染（UTIs）的经验性治疗时应予以重视。敏感性信息是提供可靠治疗的基础。本研究旨在确定从位于土耳其南部和地中海地区东部的库库罗瓦州立医院的尿培养中分离出的细菌的抗生素敏感性。
回顾性评估2018年4月至2021年1月期间的尿培养结果。还记录了年龄、性别和医疗科室等变量。纳入标准为年龄至少18岁且尿培养中有病原菌生长的患者。使用VITEK 2自动化系统进行抗生素敏感性测试和细菌鉴定。
在12288份尿样中，2033份（16.5%）有病原菌生长。细菌和酵母菌生长率分别为93.3%和6.7%。革兰氏阴性病原体占该队列的91.6%。最常见的细菌是 ，占比66%，其次是 （14.2%）。根据我们的结果，环丙沙星、甲氧苄啶 - 磺胺甲恶唑和氨苄西林不适合用于UTIs的经验性治疗，而呋喃妥因和磷霉素是合理的选择。
尿路病原体对氨苄西林、甲氧苄啶 - 磺胺甲恶唑和环丙沙星的耐药率有所增加。呋喃妥因、磷霉素和头孢他啶在尿培养中对常见尿路病原体的疗效优于其他研究的抗生素，适用于UTI的经验性治疗。
需注意，原文中部分细菌名称未完整给出，翻译时保留了原文格式。
