Zhu Xiao-Yu, Ma Ting-Ting, Li Yang, Zhang Ming-Qi, Zhao Liang, Liang Jia, Min Lian-Qiu
Department of Neurology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning Province, China.
Institution of Life Science, Jinzhou Medical University, Jinzhou, Liaoning Province, China.
Neural Regen Res. 2023 Apr;18(4):869-874. doi: 10.4103/1673-5374.353500.
Recent research on the underlying mechanisms of cerebral ischemia indicates that the neurovascular unit can be used as a novel subject for general surveys of neuronal damage and protein mechanisms. Fingolimod (FTY-720) is a newly developed immunosuppressant isolated from Cordyceps sinensis that exhibits a wide range of biological activities, and has recently attracted much attention for the treatment of ischemic cerebrovascular diseases. In the current research, the role of FTY-720 and its possible mechanisms were assessed from an neurovascular unit perspective using a rat cerebral ischemia model. Our results revealed that FTY-720 markedly decreased infarct volume, promoted neurological function recovery, and weakened the blood-brain barrier permeability of ischemic rats. The protective roles of FTY-720 in ischemic stroke are ascribed to a combination of sphingosin-1-phosphate receptor-1 and reduced expression of sphingosin-1-phosphate receptor-1 in microvessels and reduction of interleukin-17A protein levels. These findings indicate that FTY-720 has promise as a new therapy for neurovascular protection and functional recovery after ischemic stroke.
近期关于脑缺血潜在机制的研究表明，神经血管单元可作为神经元损伤和蛋白质机制综合研究的新对象。芬戈莫德（FTY-720）是一种新开发的从冬虫夏草中分离出的免疫抑制剂，具有广泛的生物学活性，最近在缺血性脑血管疾病治疗方面备受关注。在当前研究中，使用大鼠脑缺血模型从神经血管单元角度评估了FTY-720的作用及其可能机制。我们的结果显示，FTY-720显著降低了梗死体积，促进了神经功能恢复，并减弱了缺血大鼠的血脑屏障通透性。FTY-720在缺血性卒中中的保护作用归因于鞘氨醇-1-磷酸受体-1的结合以及微血管中鞘氨醇-1-磷酸受体-1表达的降低和白细胞介素-17A蛋白水平的降低。这些发现表明，FTY-720有望成为缺血性卒中后神经血管保护和功能恢复的新疗法。
