Kholodenko B N
Biofizika. 1987 May-Jun;32(3):424-8.
Relationship was studied between the stability degree of the metabolic chain with one loop of the negative feedback and force of coupling and values of characteristic times of the chain reactions. For the chain with arbitrary values of characteristic times of individual stages the maximal possible degree of the chain stability and corresponding value of the feedback coefficient are estimated. It has been shown that the increase of the characteristic time of one (no more) reaction and decrease of the sum of characteristic times of other reactions which it is of advantage to make equal makes it possible to combine high degree of dynamic stability and consequently sufficient rate of transitory processes in the chain with a high quality of stabilization of the final product, i.e. with a strong negative feedback.
研究了具有单环负反馈的代谢链的稳定程度与耦合力以及链反应特征时间值之间的关系。对于各阶段特征时间具有任意值的链，估计了链的最大可能稳定程度和相应的反馈系数值。结果表明，使一个（不多于一个）反应的特征时间增加，而使与之有利相等的其他反应的特征时间之和减小，就有可能在链中兼具高度的动态稳定性以及因此足够的瞬态过程速率，同时又具有高质量的最终产物稳定化，即具有强负反馈。
