Gumus Kemal, Demir Mehmet, Dag Ismail
Department of Urology, Balikligol Government Hospital, Sanliurfa, Turkey.
Department of Urology, Harran University, Sanliurfa, Turkey.
J Coll Physicians Surg Pak. 2022 Oct;32(10):1238-1241. doi: 10.29271/jcpsp.2022.10.1238.
To investigate the serum versus insulin-like peptide-6 (INSL-6) levels in men with non-obstructive azoospermia (NOA) and normospermia.
Descriptive study.
Department of Urology, Balikligol State Hospital and Harran University, Sanliurfa, Turkey, between July and October 2020.
The serum and seminal levels of INSL-6 were measured in men with NOA, and normospermia using a commercially available enzyme-linked immunosorbent assay. Age, body mass index (BMI), hormone profile, testicular volumes and seminal and serum INSL-6 levels were compared between the study groups.
In total, 80 men were included in the study, 40 of whom have NOA and 40 have normospermia. No significant difference was found in the mean age and BMI between the groups (p >0.05). Seminal INSL-6 levels were higher in the normospermia group, although serum and seminal INSL-6 levels were not significantly different in this group (p >0.05). No significant correlation was observed between serum INSL-6 levels and age, BMI,testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and varicocele presence (p >0.05). No significant association was found between seminal INSL-6 levels and age, BMI, FSH, LH, and testosterone levels (p >0.05). However, a significant negative association observed between seminal INSL-6 levels and testicular volume (p <0.05).
The seminal INSL-6 levels were approximately 5.5 times higher than the serum INSL-6 levels and survival level of INSL-6 were higher in the normospermia. This suggests that INSL-6 plays an active role in the male reproductive system. However, the mechanism and extent of this effect remain to be elucidated.
Infertility, Non-obstructive azoospermia, Insulin-like peptide-6.
研究非梗阻性无精子症（NOA）男性与正常精子症男性的血清胰岛素样肽-6（INSL-6）水平。
描述性研究。
2020年7月至10月期间，土耳其加济安泰普市巴利克利戈尔州立医院和哈兰大学泌尿外科。
使用市售酶联免疫吸附测定法测量NOA男性和正常精子症男性的血清和精液中INSL-6水平。比较研究组之间的年龄、体重指数（BMI）、激素谱、睾丸体积以及精液和血清INSL-6水平。
本研究共纳入80名男性，其中40名患有NOA，40名患有正常精子症。两组之间的平均年龄和BMI无显著差异（p>0.05）。正常精子症组的精液INSL-6水平较高，尽管该组的血清和精液INSL-6水平无显著差异（p>0.05）。血清INSL-6水平与年龄、BMI、睾酮、促卵泡激素（FSH）、促黄体生成素（LH）和精索静脉曲张的存在无显著相关性（p>0.05）。精液INSL-6水平与年龄、BMI、FSH、LH和睾酮水平之间未发现显著关联（p>0.05）。然而，精液INSL-6水平与睾丸体积之间存在显著负相关（p<0.05）。
精液INSL-6水平约为血清INSL-6水平的5.5倍，且正常精子症中INSL-6的存活水平更高。这表明INSL-6在男性生殖系统中发挥着积极作用。然而，这种作用的机制和程度仍有待阐明。
不育症；非梗阻性无精子症；胰岛素样肽-6
