Al-Khamis K I, Kaka J S, Matar K M
Biopharm Drug Dispos. 1987 Jul-Aug;8(4):319-25. doi: 10.1002/bdd.2510080403.
Cimetidine and ranitidine absorption were studied after oral administration to rabbits, alone or in combination with oral and intravenous domperidone. Blood samples were collected before and 0.25, 0.5, 0.75, 1.0, 1.5, 2.0, 3.0, 4.5, and 6.0 h after cimetidine and ranitidine administration. Assays of cimetidine and ranitidine in plasma samples were carried out using HPLC method. Domperidone overall significantly reduced the area under the plasma concentration-time curve (AUC) by approximately 30 per cent for both drugs. However, domperidone had little effect on the maximum plasma concentration (Cmax), the time taken to reach the maximum plasma concentration (Tmax), and the elimination half-life (t1/2) of cimetidine and ranitidine. The results suggest that domperidone affects the extent but not the rate of cimetidine and ranitidine absorption by enhancing gastric emptying.
对兔子口服西咪替丁和雷尼替丁，单独给药或与口服及静脉注射多潘立酮联合给药后，研究了它们的吸收情况。在给予西咪替丁和雷尼替丁之前以及给药后0.25、0.5、0.75、1.0、1.5、2.0、3.0、4.5和6.0小时采集血样。使用高效液相色谱法对血浆样本中的西咪替丁和雷尼替丁进行测定。多潘立酮总体上使两种药物的血浆浓度-时间曲线下面积（AUC）显著降低了约30%。然而，多潘立酮对西咪替丁和雷尼替丁的最大血浆浓度（Cmax）、达到最大血浆浓度所需的时间（Tmax）以及消除半衰期（t1/2）几乎没有影响。结果表明，多潘立酮通过促进胃排空影响西咪替丁和雷尼替丁的吸收程度，但不影响其吸收速率。
