快速脓毒症相关器官衰竭评估评分可预测酒精性胰腺炎患者的胰腺炎严重程度。

The Quick Sepsis-Related Organ Failure Assessment Score Is Prognostic of Pancreatitis Severity in Patients With Alcohol-Induced Pancreatitis.

机构信息

From the Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston.

Department of Internal Medicine, Division of Digestive and Liver Diseases, University of Texas Southwestern, Dallas.

出版信息

Pancreas. 2022 Jul 1;51(6):694-699. doi: 10.1097/MPA.0000000000002095.

DOI:10.1097/MPA.0000000000002095

PMID:36206471

Abstract

OBJECTIVES

The aim of this study was to determine if the quick Sepsis-Related Organ Failure Assessment (qSOFA) score assessed at and 48 hours after admission is prognostic for alcohol-induced acute pancreatitis (AAP) severity.

METHODS

This is a retrospective cohort review study of 161 patients admitted to a single academic hospital in Houston, TX, with the diagnosis of AAP. Receiver operator characteristics analysis and logistic regression were used to assess the diagnostic accuracy and prognostic ability of the qSOFA score.

RESULTS

A qSOFA score of 2 or higher at and 48 hours after admission had a specificity of 94% or greater and sensitivity of 33% or higher for pancreatitis severity and need for intensive care admission, intubation, or vasopressors. The qSOFA score at and 48 hours after admission was prognostic of intensive care unit admission by an adjusted odds ratio of 48.5 (95% confidence interval [CI], 6.4-1013.3; P < 0.001) and 18.8 (95% CI, 2.2-467.3; P < 0.05), respectively. The qSOFA score at admission was prognostic of severe pancreatitis by an adjusted odds ratio of 35.3 (95% CI, 7.2-224.3; P < 0.001).

CONCLUSIONS

A qSOFA score of 2 or higher is highly specific and prognostic of multiple clinical outcomes both at and 48 hours after admission in patients with AAP.

摘要

目的

本研究旨在确定入院时和入院后 48 小时快速脓毒症相关器官衰竭评估（qSOFA）评分是否与酒精性急性胰腺炎（AAP）严重程度相关。

方法

这是一项回顾性队列研究，纳入了 161 名在德克萨斯州休斯顿的一家学术医院就诊的 AAP 患者。使用受试者工作特征曲线分析和逻辑回归来评估 qSOFA 评分的诊断准确性和预后能力。

结果

入院时和入院后 48 小时 qSOFA 评分≥2 分对胰腺炎严重程度和需要入住重症监护病房、气管插管或血管升压药的预测具有 94%或更高的特异性和 33%或更高的敏感性。入院时和入院后 48 小时的 qSOFA 评分是入住重症监护病房的预后指标，校正后比值比分别为 48.5（95%置信区间，6.4-1013.3；P＜0.001）和 18.8（95%置信区间，2.2-467.3；P＜0.05）。入院时的 qSOFA 评分是严重胰腺炎的预后指标，校正后比值比为 35.3（95%置信区间，7.2-224.3；P＜0.001）。