Department of Agroindustrial Technology and Rural Socioeconomics, Center of Agricultural Sciences, Federal University of São Carlos (UFSCar), Rodovia Anhanguera, km 174, ZC 13.600-970 Araras, SP, Brazil.
Department of Agroindustrial Technology and Rural Socioeconomics, Center of Agricultural Sciences, Federal University of São Carlos (UFSCar), Rodovia Anhanguera, km 174, ZC 13.600-970 Araras, SP, Brazil.
J Biotechnol. 2022 Nov 20;359:116-129. doi: 10.1016/j.jbiotec.2022.09.020. Epub 2022 Oct 4.
The concern for better life quality has been encouraging the bioprocess industries to develop technological strategies to obtain new biomolecules. Galactooligosaccharides (GOS) are an important class of food-grade oligosaccharides, being classified as non-digestible, and which present prebiotic potential, promoting better conditions of health and well-being. The main benefits include the selective stimulation of beneficial microorganisms, the decrease in the formation of toxic compounds, the increase in the absorption of minerals, improvement of an immune response, and a reduction in the severity of obesity and diabetes. This review approaches the recent methodologies and strategies to obtain GOS, their health benefits, purification, and technological properties for industrial application. Improvements in the process are continuously being investigated, with the technique of enzyme immobilization representing a potentially promising strategy. Sustainable GOS productions have been reported by the use of agro-industrial residues, such as cheese whey. Despite these advances, the main concern of the process consists in the low yield, which implies high investments in the purification of the bioproducts. Technological and nutritional approaches to the GOS application in different industrial sectors are also reported.
对更好生活质量的关注一直鼓励着生物工艺行业开发技术策略来获取新的生物分子。半乳糖低聚糖（GOS）是一类重要的食品级低聚糖，被归类为不可消化的物质，具有益生元的潜力，可促进健康和幸福状况的改善。主要益处包括选择性刺激有益微生物、减少有毒化合物的形成、增加矿物质吸收、改善免疫反应以及减轻肥胖和糖尿病的严重程度。本文综述了获得 GOS 的最新方法和策略、它们的健康益处、纯化以及工业应用的技术特性。人们一直在不断研究改进该工艺，酶固定化技术代表了一种很有前途的策略。使用奶酪乳清等农业工业副产物已经报道了可持续的 GOS 生产。尽管取得了这些进展，但该工艺的主要关注点仍然是产量低，这意味着在生物制品的纯化方面需要大量投资。本文还报道了 GOS 在不同工业领域的应用的技术和营养方法。
