Division of Cardiology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Division of Cardiology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Trends Mol Med. 2022 Dec;28(12):1040-1049. doi: 10.1016/j.molmed.2022.09.006. Epub 2022 Oct 4.
Chronic stress is often regarded as a significant cause of morbidity and mortality; however, the mechanistic link between stress and various disease states has not yet been fully characterized. We explore the concept of allostatic load, a measurement of the physiological burden of chronic stress, as well as its potential role in disease pathogenesis as it relates to cardiovascular disease, cancer, and health-related disparities. Building from this framework, we then posit the potential implications of allostatic load on patient care and research in cardio-oncology. We identify allostatic load as a potential clinically actionable tool to improve health equity in cardio-oncology.
慢性应激通常被认为是发病率和死亡率的重要原因；然而，应激与各种疾病状态之间的机制联系尚未得到充分描述。我们探讨了适应负荷的概念，即衡量慢性应激的生理负担的一种方法，以及它在心血管疾病、癌症和与健康相关的差异方面对疾病发病机制的潜在作用。在此框架的基础上，我们进一步提出适应负荷对心脏肿瘤学患者护理和研究的潜在影响。我们将适应负荷视为改善心脏肿瘤学中健康公平的潜在临床可行工具。
