Hoshide Satoshi, Kubota Kana, Kario Kazuomi
Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University, Tochigi, Japan.
Hypertens Res. 2023 Mar;46(3):751-755. doi: 10.1038/s41440-022-01054-4. Epub 2022 Oct 7.
The aim of this study was to determine the independent association of nocturnal hypoxia with morning minus evening home blood pressure (MEdif) in a cohort of outpatients with at least one cardiovascular risk. A total of 1053 participants underwent home blood pressure (BP) portable pulse oximetry measurements, and 147 (14%) had an MEdif ≥20 mmHg, where MEdif was defined as the difference between morning and evening home systolic BP. When participants were divided into quartiles according to the lowest oxygen saturation (SpO) during the nighttime, those in the lowest quartile (range, 54-79%) were significantly more likely to have MEdif ≥20 mmHg than those in the top quartile (range, 89-97%) (adjusted odds ratio, 1.98; 95% confidence interval, 1.13-3.49). The present study revealed an association between lowest SpO during the nighttime and increased MEdif in a cohort of outpatients with at least one cardiovascular risk.
本研究的目的是在一组至少有一项心血管风险的门诊患者中，确定夜间低氧血症与早晨减去晚上家庭血压（MEdif）之间的独立关联。共有1053名参与者进行了家庭血压（BP）和便携式脉搏血氧饱和度测量，其中147名（14%）的MEdif≥20 mmHg，MEdif定义为早晨和晚上家庭收缩压之差。当根据夜间最低血氧饱和度（SpO）将参与者分为四分位数时，最低四分位数组（范围为54 - 79%）的参与者比最高四分位数组（范围为89 - 97%）的参与者更有可能出现MEdif≥20 mmHg（调整后的优势比为1.98；95%置信区间为1.13 - 3.49）。本研究揭示了在一组至少有一项心血管风险的门诊患者中，夜间最低SpO与MEdif升高之间的关联。
