HIV 感染早期开始抗逆转录病毒治疗的意义。
Significance of initiating antiretroviral therapy in the early stage of HIV infection.
机构信息
Department of Infectious Diseases and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Department of Infectious Diseases, National Clinical Research Center for Infectious Diseases, the Third People's Hospital of Shenzhen, the Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518112, Guangdong Province, China.
出版信息
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2022 Jun 25;51(3):373-379. doi: 10.3724/zdxbyxb-2022-0052.
A growing number of guidelines now recommend that human immunodeficiency virus (HIV) infected patients should be given early antiretroviral therapy (ART), especially in acute HIV infection. ART during early infection can limit viral reservoirs and improve immune cell function. From a societal prospect, early-infected individuals who achieve a state of viral suppression through ART can reduce the chance of HIV transmission and reduce the acquired immunodeficiency syndrome (AIDS)-related disease burden. However, there are many problems in the early diagnosis and treatment of HIV infection, including personal and social factors, which hinder the implementation and development of early treatment. It is recommended that initiating ART in the early stage of HIV infection, combined with other treatment strategies, so as to achieve functional cure.
越来越多的指南建议感染人类免疫缺陷病毒(HIV)的患者应尽早接受抗逆转录病毒治疗(ART),尤其是在急性 HIV 感染期。早期感染期进行 ART 可以限制病毒储存库并改善免疫细胞功能。从社会角度来看,通过 ART 实现病毒抑制的早期感染者可以降低 HIV 传播的机会,并减轻与获得性免疫缺陷综合征(AIDS)相关的疾病负担。然而,HIV 感染的早期诊断和治疗存在许多问题,包括个人和社会因素,这些因素阻碍了早期治疗的实施和发展。建议在 HIV 感染的早期阶段启动 ART,并结合其他治疗策略,以实现功能性治愈。
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