Jiang Y, He F C
State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.
Zhonghua Gan Zang Bing Za Zhi. 2022 Aug 20;30(8):797-802. doi: 10.3760/cma.j.cn501113-20220616-00328.
Proteomics is the study of proteins-the direct executor of life activities. Protein plays a vital role in the development and growth of human body and the genesis and development of diseases. It is the most widely used clinical marker type and the direct drug target. In recent years, the advance of proteomic core technology with chromatography and mass spectrometry has promoted the rapid development in the depth and breadth of proteomic research, and its application in the large cohort of hepatocellular carcinoma opens a new era of proteomics-driven precision medicine (PDPM). This review highlights the proteomic research in new techniques, directions and discoveries of hepatocellular carcinoma research in recent years, providing new ideas and references for clinicians to understand proteomics, and to use proteomics to assist in the diagnosis of diseases and the development of personalized therapies.
蛋白质组学是对蛋白质的研究——生命活动的直接执行者。蛋白质在人体的发育和生长以及疾病的发生和发展中起着至关重要的作用。它是临床应用最为广泛的标志物类型和直接的药物靶点。近年来，基于色谱和质谱的蛋白质组学核心技术的进步推动了蛋白质组学研究在深度和广度上的快速发展，其在大规模肝细胞癌队列中的应用开启了蛋白质组学驱动的精准医学（PDPM）新时代。本综述重点介绍了近年来肝细胞癌研究在新技术、新方向和新发现方面的蛋白质组学研究，为临床医生了解蛋白质组学、利用蛋白质组学辅助疾病诊断和个性化治疗方案的制定提供新思路和参考。
