Deng M H, Zhang S Y, Wang Y
PLA Rocket Force Characteristic Medical Center, Beijing 100088, China.
Zhonghua Jie He He Hu Xi Za Zhi. 2022 Oct 12;45(10):1041-1045. doi: 10.3760/cma.j.cn112147-20220110-00034.
The burden of tuberculosis remains high in China. Although successfully cured of tuberculosis, a large proportion of patients still suffer from post-tuberculosis lung disease (PTLD), causing great harm to individuals and societies. PTLD is a group of heterogeneous disorders that affects airways, lung parenchyma, pleura, and/or pulmonary vasculature. The related etiology and pathogenesis remain unclear, and are likely the result of the interplay between the host immune responses, pathogens, and environmental factors. Advances in prevention and treatment mainly involve adjuvant therapy and pulmonary rehabilitation. Since PTLD patients mostly visit respiratory departments for consultation, it is essential for respiratory physicians to improve the awareness PTLD, and therefore the research progress of PTLD is reviewed.
在中国,结核病负担依然沉重。尽管大部分患者成功治愈了结核病,但仍有很大比例的患者患有结核病后肺部疾病(PTLD),这对个人和社会造成了极大危害。PTLD是一组异质性疾病,可累及气道、肺实质、胸膜和/或肺血管系统。其相关病因和发病机制尚不清楚,可能是宿主免疫反应、病原体和环境因素相互作用的结果。预防和治疗方面的进展主要包括辅助治疗和肺康复。由于PTLD患者大多前往呼吸科就诊,因此呼吸科医生提高对PTLD的认识至关重要,故对PTLD的研究进展进行综述。