Department of Immunology, School of Basic Medicine, Gannan Medical University, Ganzhou, 341000, Jiangxi, PR China; Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Gannan Medical University, Ganzhou, 341000, Jiangxi, PR China; Henan Key Laboratory of Immunology and Targeted Drugs, Xinxiang Medical University, Xinxiang, 453003, Henan, PR China.
Department of Immunology, School of Basic Medicine, Gannan Medical University, Ganzhou, 341000, Jiangxi, PR China.
Virology. 2022 Nov;576:111-116. doi: 10.1016/j.virol.2022.09.011. Epub 2022 Oct 6.
The hepatocytes, as the main cells in the liver, exert liver functions by expressing innate immune receptors. The innate immune receptors include Toll-like receptors (TLRs), RIG-like receptors (retinoic acid inducible gene I-like receptors, RLRs) and NOD-like receptors (nucleotide binding oligomerization domain-like receptors, NLRs). The hepatocytes, recognize extracellular pathogen-associated molecular patterns (PAMPs) and intracellular damage-associated molecular patterns (DAMPs) through the above receptors. After the activation of the innate immune receptors, the hepatocytes produce cytokines, such as interferon (IFN), to protect the liver, through a series of signaling cascades.
肝细胞作为肝脏的主要细胞，通过表达先天免疫受体发挥肝脏功能。先天免疫受体包括 Toll 样受体 (TLRs)、视黄酸诱导基因 I 样受体 (RLRs) 和核苷酸结合寡聚化结构域样受体 (NLRs)。肝细胞通过上述受体识别细胞外病原体相关分子模式 (PAMPs) 和细胞内损伤相关分子模式 (DAMPs)。先天免疫受体激活后，肝细胞通过一系列信号级联反应产生细胞因子，如干扰素 (IFN)，以保护肝脏。
