University of Washington School of Medicine, Seattle Children's Hospital, 4800 Sand Point Way Northeast, Seattle, WA 98105, USA.
University of Washington School of Medicine, Seattle Children's Hospital, 4800 Sand Point Way Northeast, Seattle, WA 98105, USA.
Surg Clin North Am. 2022 Oct;102(5):861-872. doi: 10.1016/j.suc.2022.07.015. Epub 2022 Sep 13.
Medical and surgical care for children with intestinal failure has evolved so that long-term life expectancy is common even in the setting of the shortest bowel lengths. The long-term administration of parenteral nutrition has become safe with alterations in lipid formulation, and the risk of liver injury has been dramatically reduced. Well-established techniques for bowel lengthening and tapering exist to increase the absorptive capacity of the remnant bowel. These advances allow for ongoing intestinal rehabilitation in the child with the ultimate goal of enteral autonomy while the use of intestinal transplantation in this population has declined in recent years.
儿童肠衰竭的医疗和外科治疗已经发展到即使在最短肠段的情况下，长期预期寿命也很常见。通过改变脂肪配方，长期进行肠外营养已变得安全，肝损伤的风险大大降低。现有的肠延长和变细技术可增加残留肠的吸收能力。这些进展使患有肠衰竭的儿童能够进行持续的肠道康复，最终目标是实现肠内自主，而近年来，该人群中肠移植的使用已经减少。
