Zhu Ming-Xi, Ma Xiao-Fei, Niu Xing, Fan Gui-Bo, Li Yan
Department of Anatomy, School of Basic Medicine and Life Science, Hainan Medical University, Hainan, China.
Department of ICU, The 4th Affiliated Hospital of Harbin Medical University, Harbin, China.
Brain Res. 2022 Dec 15;1797:148116. doi: 10.1016/j.brainres.2022.148116. Epub 2022 Oct 6.
Mitochondrial unfolded protein response (UPR) is a mitochondrial stress response that activates the transcriptional program of mitochondrial chaperone proteins and proteases to keep protein homeostasis in mitochondria. Ischemia-reperfusion injury results in multiple severe clinical issues linked to high morbidity and mortality in various disorders. The pathophysiology and pathogenesis of ischemia-reperfusion injury are complex and multifactorial. Emerging evidence showed the roles of UPR signaling in ischemia-reperfusion injury. Herein, we discuss the regulatory mechanisms underlying UPR signaling in C. elegans and mammals. Furthermore, we review the recent studies into the roles and mechanisms of UPR signaling in ischemia-reperfusion injury of the heart, brain, kidney, and liver. Further research of UPR signaling will potentially develop novel therapeutic strategies against ischemia-reperfusion injury.
线粒体未折叠蛋白反应（UPR）是一种线粒体应激反应，它激活线粒体伴侣蛋白和蛋白酶的转录程序，以维持线粒体中的蛋白质稳态。缺血再灌注损伤会导致多种严重的临床问题，这些问题与各种疾病的高发病率和死亡率相关。缺血再灌注损伤的病理生理学和发病机制复杂且多因素。新出现的证据表明了UPR信号在缺血再灌注损伤中的作用。在此，我们讨论秀丽隐杆线虫和哺乳动物中UPR信号的调控机制。此外，我们回顾了最近关于UPR信号在心脏、大脑、肾脏和肝脏缺血再灌注损伤中的作用和机制的研究。对UPR信号的进一步研究可能会开发出针对缺血再灌注损伤的新型治疗策略。
