病例报告：一名6岁女童以皮肤白血病作为慢性嗜中性粒细胞白血病的首发表现。
Case report: Leukemia cutis as the first manifestation of chronic neutrophilic leukemia in a 6-year-old girl.
作者信息
Zhou Ya Bin, Yao Jia Feng, Xu Zi Gang, Wu Rui Hui
机构信息
Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Second Hematology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
出版信息
Front Pediatr. 2022 Sep 21;10:972224. doi: 10.3389/fped.2022.972224. eCollection 2022.
Chronic neutrophilic leukemia (CNL) is a rare negative myeloproliferative neoplasm that usually affects older adults with a poor prognosis. Leukemia cutis is an extramedullary manifestation of leukemia and may be misdiagnosed by dermatologists. Here, we describe a case of CNL in a 6-year-old Chinese girl with leukemia cutis as the first manifestation. Her skin rashes failed to attract the attention of dermatologists in early stages. The diagnosis was confirmed by peripheral smear, bone marrow studies, genomic analysis and skin biopsy.
慢性嗜中性粒细胞白血病（CNL）是一种罕见的阴性骨髓增殖性肿瘤，通常影响老年人，预后较差。白血病性皮肤浸润是白血病的一种髓外表现，可能会被皮肤科医生误诊。在此，我们描述了一例6岁中国女孩以白血病性皮肤浸润为首发表现的CNL病例。她的皮疹在早期早期早期未能引起皮肤科医生在早期的注意。通过外周血涂片、骨髓检查、基因组分析和皮肤活检确诊。
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