癌症中的PIWI相互作用RNA：生物发生、功能及临床意义
PIWI-interacting RNAs in cancer: Biogenesis, function, and clinical significance.
作者信息
Yao Jie, Xie Mei, Ma Xidong, Song Jialin, Wang Yuanyong, Xue Xinying
机构信息
Department of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Department of Respiratory and Critical Care, The Chinese People's Liberation Army of China (PLA) General Hospital, Beijing, China.
出版信息
Front Oncol. 2022 Sep 23;12:965684. doi: 10.3389/fonc.2022.965684. eCollection 2022.
PIWI-interacting RNAs (piRNAs) are a less-studied class of small non-coding RNAs approximately 24-31 nucleotides in length. They express in germline and somatic cells and form complexes with PIWI proteins to exert regulatory effects. New studies show that piRNAs are aberrantly expressed in various cancers. In this review, we focus on those piRNAs that are associated with cancer hallmarks such as proliferation, invasion, and chemoresistance and discuss their potential as biomarkers for cancer diagnosis and prognosis.
PIWI相互作用RNA（piRNA）是一类研究较少的小非编码RNA，长度约为24 - 31个核苷酸。它们在生殖细胞和体细胞中表达，并与PIWI蛋白形成复合物以发挥调节作用。新研究表明，piRNA在多种癌症中异常表达。在本综述中，我们聚焦于那些与增殖、侵袭和化疗耐药等癌症特征相关的piRNA，并讨论它们作为癌症诊断和预后生物标志物的潜力。
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