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Safety study supports clinical development of immunotherapeutic oncolytic measles vaccine.

作者信息

Engeland Christine E

机构信息

Faculty of Health/School of Medicine, Institute of Virology and Microbiology - Experimental Virology, Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Witten, Germany.

Research Group Mechanisms of Oncolytic Immunotherapy, Clinical Cooperation Unit Virotherapy, German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT) and University Hospital Heidelberg, Department of Medical Oncology, Heidelberg, Germany.

出版信息

Mol Ther Methods Clin Dev. 2022 Sep 24;27:90-92. doi: 10.1016/j.omtm.2022.09.003. eCollection 2022 Dec 8.

DOI:10.1016/j.omtm.2022.09.003
PMID:36212907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9515431/
Abstract
摘要

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Mol Ther Methods Clin Dev. 2022 Jul 31;26:532-546. doi: 10.1016/j.omtm.2022.07.014. eCollection 2022 Sep 8.
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Oncolytic measles vaccines encoding PD-1 and PD-L1 checkpoint blocking antibodies to increase tumor-specific T cell memory.编码程序性死亡蛋白1（PD-1）和程序性死亡配体1（PD-L1）检查点阻断抗体的溶瘤麻疹疫苗，以增强肿瘤特异性T细胞记忆。
Mol Ther Oncolytics. 2021 Nov 29;24:43-58. doi: 10.1016/j.omto.2021.11.020. eCollection 2022 Mar 17.
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J Clin Invest. 2021 Jul 1;131(13). doi: 10.1172/JCI141614.
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Measles Virus as an Oncolytic Immunotherapy.麻疹病毒作为一种溶瘤免疫疗法。
Cancers (Basel). 2021 Feb 1;13(3):544. doi: 10.3390/cancers13030544.
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Cytokine Growth Factor Rev. 2020 Dec;56:28-38. doi: 10.1016/j.cytogfr.2020.07.009. Epub 2020 Jul 3.
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