Huang Jiayang, Zhang Yusi, Zhang Qi, Wei Linxuan, Zhang Xiwen, Jin Caiping, Yang Junchao, Li Zuanfang, Liang Shengxiang
National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Rehabilitation Industry Institute, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Front Neurosci. 2022 Sep 23;16:963175. doi: 10.3389/fnins.2022.963175. eCollection 2022.
As a non-radiative, non-invasive imaging technique, functional magnetic resonance imaging (fMRI) has excellent effects on studying the activation of blood oxygen levels and functional connectivity of the brain in human and animal models. Compared with resting-state fMRI, fMRI combined with stimulation could be used to assess the activation of specific brain regions and the connectivity of specific pathways and achieve better signal capture with a clear purpose and more significant results. Various fMRI methods and specific stimulation paradigms have been proposed to investigate brain activation in a specific state, such as electrical, mechanical, visual, olfactory, and direct brain stimulation. In this review, the studies on animal brain activation using fMRI combined with different stimulation methods were retrieved. The instruments, experimental parameters, anesthesia, and animal models in different stimulation conditions were summarized. The findings would provide a reference for studies on estimating specific brain activation using fMRI combined with stimulation.
作为一种非辐射、非侵入性成像技术，功能磁共振成像（fMRI）在研究人类和动物模型中脑血氧水平的激活及脑功能连接方面具有出色效果。与静息态fMRI相比，结合刺激的fMRI可用于评估特定脑区的激活及特定通路的连接性，能更有针对性地实现更好的信号捕捉，结果也更显著。已提出了各种fMRI方法和特定刺激范式来研究特定状态下的脑激活，如电刺激、机械刺激、视觉刺激、嗅觉刺激和直接脑刺激。在本综述中，检索了使用fMRI结合不同刺激方法对动物脑激活的研究。总结了不同刺激条件下的仪器、实验参数、麻醉和动物模型。这些研究结果将为利用fMRI结合刺激来评估特定脑激活的研究提供参考。
