Servicio Urología, Hospital Universitario Joan XXIII, Tarragona, España.
Servicio de Urología, Hospital Universitario Son Espases, Palma de Mallorca, España.
Arch Esp Urol. 2022 Sep;75(7):612-617. doi: 10.56434/j.arch.esp.urol.20227507.88.
Expansion of the donor pool has been enabled by the use of donation after circulatory death (DCD). The aim of this study is to identify what donation features are able to predict kidney transplant (KT) outcomes from DCD.
A prospective analysis of all DCD KT from June 2016 to November 2019 was conducted. Association between donor and recipient features, and ischemia times with delayed graft function (DGF) and serum creatinine (Cr) at discharge, and at three and twelve months were analysed.
A total of 86 KT were performed. The results revealed a relationship between donor age ( = 0.014) and receptors on haemodialysis ( = 0.001) with DGF. There was no association between different ischemia times and DGF. Residual urine output greater than 500mL/day and being on peritoneal dialysis were found to be protective factors for DGF. Correlation analysis illustrated a significant correlation between donor age and Cr at discharge and at 3 months.
Higher donor age and being on haemodialysis were risk factors for DGF. Likewise, donor age did not show a significant association with 12-month serum Cr. These results demonstrate that donor age is a risk factor for DGF but does not affect long term graft function.
通过使用死后循环死亡（DCD），已经可以扩大供体库。本研究的目的是确定哪些供体特征能够预测来自 DCD 的肾移植（KT）结果。
对 2016 年 6 月至 2019 年 11 月期间所有 DCD-KT 进行了前瞻性分析。分析了供体和受体特征，以及缺血时间与延迟移植物功能障碍（DGF）和出院时、第 3 个月和第 12 个月的血清肌酐（Cr）之间的关系。
共进行了 86 例 KT。结果显示，供体年龄（=0.014）和血液透析受体（=0.001）与 DGF 之间存在关系。不同的缺血时间与 DGF 之间没有关联。发现每天残余尿量大于 500ml 和腹膜透析是 DGF 的保护因素。相关分析表明，供体年龄与出院时和第 3 个月的 Cr 之间存在显著相关性。
较高的供体年龄和血液透析是 DGF 的危险因素。同样，供体年龄与 12 个月时的血清 Cr 无显著相关性。这些结果表明，供体年龄是 DGF 的一个危险因素，但不会影响长期移植物功能。
