钌催化的二芳基1,4 - 二酮对映选择性氢化反应：手性1,4 - 二芳基丁烷 - 1,4 - 二醇的合成
Ru-Catalyzed Enantioselective Hydrogenation of Diaryl 1,4-Diketones: Synthesis of Chiral 1,4-Diarylbutane-1,4-Diols.
作者信息
Zhang Yuxuan, Li Xiaotong, Xu Limin, Xie Xiaomin, Lu Yan, Zhang Zhaoguo
机构信息
Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
出版信息
Org Lett. 2022 Oct 21;24(41):7512-7516. doi: 10.1021/acs.orglett.2c02721. Epub 2022 Oct 10.
Asymmetric hydrogenation of diaryl 1,4-diketones was achieved by using -RuCl[()-BINAP)][()-Daipen] as the catalyst and the reaction gave rise to excellent enantio- and diastereoselectivities (up to >99% and ). This procedure provides a convenient and efficient synthetic method for chiral 1,4-diarylbutane-1,4-diols, which are important intermediates for a variety of chiral auxiliaries and ligands.
以-RuCl[()-BINAP)][()-Daipen]为催化剂实现了二芳基1,4-二酮的不对称氢化反应，该反应具有优异的对映选择性和非对映选择性（高达>99% ）。此方法为手性1,4-二芳基丁烷-1,4-二醇提供了一种便捷高效的合成方法，而手性1,4-二芳基丁烷-1,4-二醇是多种手性助剂和配体的重要中间体。
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