Department of Organismal Biology, Uppsala University, Norbyvägen 18A, SE-752 36, Uppsala, Sweden.
Department of Organismal Biology, Uppsala University, Norbyvägen 18A, SE-752 36, Uppsala, Sweden.
Fish Shellfish Immunol. 2022 Dec;131:1335-1342. doi: 10.1016/j.fsi.2022.10.008. Epub 2022 Oct 7.
In crustacean animals the hemocytes are key players in immunity and of crucial importance for the health of the animals. Hemocytes are mainly produced in the hematopoietic tissue and from there released into the circulation where they finally mature. In this review we summarize the latest findings about crustacean hemocyte formation. The role of the extracellular matrix and crosslinking enzyme transglutaminase is discussed. Moreover, important growth factors, transcriptional regulation and recent findings about inducers of hematopoiesis are covered. Finally, we discuss the use of different markers for classification of crustacean hemocytes.
在甲壳动物中，血细胞是免疫的关键参与者，对动物的健康至关重要。血细胞主要在造血组织中产生，并从那里释放到循环中，最终在那里成熟。在这篇综述中，我们总结了关于甲壳动物血细胞形成的最新发现。讨论了细胞外基质和交联酶转谷氨酰胺酶的作用。此外，还介绍了重要的生长因子、转录调控以及造血诱导因子的最新发现。最后，我们讨论了使用不同标志物对甲壳动物血细胞进行分类的问题。
