Hamada Ryota, Sato Susumu, Miyasaka Junsuke, Murao Masanobu, Matsushita Michiko, Kajimoto Taishi, Otagaki Ayumi, Asano Tsugumi, Nankaku Manabu, Kondo Tadakazu, Arai Yasuyuki, Kanda Junya, Takaori-Kondo Akifumi, Ikeguchi Ryosuke, Matsuda Shuichi
Rehabilitation Unit, Kyoto University Hospital, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Japan.
Department of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University, Shogoin, 54 Kawahara-cho, Sakyo-ku, Kyoto 8507, Japan.
Transplant Cell Ther. 2023 Jan;29(1):51.e1-51.e7. doi: 10.1016/j.jtct.2022.09.030. Epub 2022 Oct 7.
A decline in physical functions at the early stage of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a serious issue. Belt electrode-skeletal muscle electrical stimulation (B-SES) can induce significant muscle contractions with electrical stimulation and reduce muscle weakness. However, this approach has not been used in allo-HSCT patients. This study aimed to examine the effect of B-SES on physical function, and safety in patients during the early post-transplantation period. Forty-three adult patients who underwent B-SES after allo-HSCT were stratified into 2 groups based on the intensity of electrical stimulation (high versus low). B-SES was performed in combination with exercise therapy for 4 post-transplantation weeks. Knee extensor strength (KES) in the low B-SES group decreased significantly, whereas no change was observed in the high-intervention group. A significant positive correlation was observed between total intensity and ΔKES. A reduction in the 6-minute walking distance in the high B-SES group patients was lower than that of historical data. Two patients had B-SES-related complications including muscle pain. This study is the first to propose a new rehabilitation intervention strategy for allo-HSCT. Combined use of B-SES may be a new approach to reducing the decline of physical function in the early post-transplantation period.
异基因造血干细胞移植（allo-HSCT）早期身体功能下降是一个严重问题。带电极-骨骼肌电刺激（B-SES）可通过电刺激诱发显著的肌肉收缩并减轻肌肉无力。然而，这种方法尚未应用于allo-HSCT患者。本研究旨在探讨B-SES对移植后早期患者身体功能及安全性的影响。43例allo-HSCT后接受B-SES的成年患者根据电刺激强度（高与低）分为2组。B-SES与运动疗法联合进行，为期移植后4周。低强度B-SES组的膝关节伸肌力量（KES）显著下降，而高强度干预组未观察到变化。总强度与KES变化量之间存在显著正相关。高强度B-SES组患者6分钟步行距离的减少低于历史数据。2例患者出现与B-SES相关的并发症，包括肌肉疼痛。本研究首次提出了一种针对allo-HSCT的新康复干预策略。联合使用B-SES可能是减少移植后早期身体功能下降的一种新方法。
