Department of Vascular and Thyroid Surgery, The First Affiliated Hospital, China Medical University, Shenyang 110001, China.
Department of Vascular and Thyroid Surgery, The First Affiliated Hospital, China Medical University, Shenyang 110001, China.
Ageing Res Rev. 2022 Dec;82:101748. doi: 10.1016/j.arr.2022.101748. Epub 2022 Oct 7.
Increasing studies have reported on the prevalence of frailty in patients with peripheral artery disease (PAD). The aim of this systematic review and meta-analysis was to estimate the pooled prevalence of frailty in patients with lower extremity PAD.
Two authors systematically searched PubMed and Embase databases from their inception to August 8, 2022. Original articles that reported the prevalence of frailty in patients with lower extremity PAD were included. The prevalence of frailty in patients with lower extremity PAD was pooled using a random-effect model. Meta-regression, subgroup, and sensitivity analyses were conducted to explore the heterogeneity.
Eighteen studies reported on 17 articles involving 1,726,343 patients with lower extremity PAD were identified. The pooled prevalence of frailty in patients with lower extremity PAD was 49 % (95 % confidence interval [CI] 37-61 %), with significant heterogeneity between studies (I = 100 %, p < 0.001). Multivariable meta-regression showed that only the severity of PAD (coefficient 0.270; 95 % CI 0.017-0.523, p = 0.039) was significantly associated with the heterogeneity. In subgroup analysis, the pooled prevalence of frailty was higher in critical limb ischemia or chronic limb-threatening ischemia (54 %) than all PAD (48 %); the pooled prevalence of frailty was 64 %, 51 %, and 54 % for Modified Frailty Index-5, Modified Frailty Index-11, and Clinical Frailty Scale, respectively. The pooled prevalence of frailty appeared to be lower in male (39 %) than the female patients (47 %).
The prevalence of frailty was higher in patients with lower extremity PAD, suggesting frailty is a common condition. This finding highlights the significance of assessing frailty in patients with lower extremity PAD.
越来越多的研究报告了外周动脉疾病（PAD）患者的衰弱患病率。本系统评价和荟萃分析的目的是估计下肢 PAD 患者衰弱的 pooled 患病率。
两位作者系统地检索了 PubMed 和 Embase 数据库，检索时间从建库到 2022 年 8 月 8 日。纳入报告下肢 PAD 患者衰弱患病率的原始文章。使用随机效应模型汇总下肢 PAD 患者衰弱的患病率。进行了荟萃回归、亚组和敏感性分析，以探索异质性。
纳入了 18 项研究报告的 17 篇文章，涉及 1726343 例下肢 PAD 患者。下肢 PAD 患者衰弱的 pooled 患病率为 49%（95%置信区间 37-61%），研究之间存在显著异质性（I = 100%，p < 0.001）。多变量荟萃回归显示，只有 PAD 的严重程度（系数 0.270；95%置信区间 0.017-0.523，p = 0.039）与异质性显著相关。在亚组分析中，严重肢体缺血或慢性肢体威胁性缺血（54%）的衰弱 pooled 患病率高于所有 PAD（48%）；修正衰弱指数-5、修正衰弱指数-11 和临床虚弱量表的衰弱 pooled 患病率分别为 64%、51%和 54%。衰弱的 pooled 患病率在男性（39%）中似乎低于女性（47%）。
下肢 PAD 患者的衰弱患病率较高，提示衰弱是一种常见病症。这一发现强调了在下肢 PAD 患者中评估衰弱的重要性。
