Department of Biomaterials and Oral Biology, University of São Paulo, Av. Prof. Lineu Prestes, 2227, São Paulo, São Paulo 05508-000, Brazil.
Department of Biomaterials and Oral Biology, University of São Paulo, Av. Prof. Lineu Prestes, 2227, São Paulo, São Paulo 05508-000, Brazil.
Dent Clin North Am. 2022 Oct;66(4):503-515. doi: 10.1016/j.cden.2022.05.002. Epub 2022 Sep 7.
The latest advancements in dentin bonding have focused on strategies to impair degradation mechanisms in order to extend the longevity of bonded interfaces. Protease inhibitors can reduce collagen degradation within the hybrid layer (HL). Collagen cross-linkers allow better adhesive infiltration and also inhibit proteases activity. Particles added to adhesive can promote mineral precipitation within the HL, reducing nanoleakage and micropermeability, besides possible antimicrobial and enzymatic inhibition effects. Most of these approaches are still experimental, and aspects of the adhesive under the clinician's control are still determinant for the long-term stability of adhesive restorations.
牙本质黏结的最新进展集中在破坏降解机制的策略上，以延长黏结界面的寿命。蛋白酶抑制剂可以减少混合层（HL）内的胶原降解。胶原交联剂可以更好地渗透到黏结剂中，并抑制蛋白酶的活性。添加到黏结剂中的颗粒可以促进 HL 内的矿物质沉淀，减少纳米渗漏和微渗透性，此外还可能具有抗菌和抑制酶的作用。这些方法大多仍处于实验阶段，并且在临床医生控制下的黏结剂的某些方面仍然是黏结修复体长期稳定性的决定因素。
