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[日本嗜酸性食管炎患者当前的真实世界治疗方法]

[Current real-world treatments for Japanese patients with eosinophilic esophagitis].

作者信息

Fujiwara Yasuhiro, Tanaka Fumio, Nakata Rieko, Kakiya Yuki, Yamamura Masafumi, Tanoue Kojiro, Sawada Akinari, Higashimori Akira, Nishida Yu, Maruyama Hirotsugu, Ominami Masaki, Nadatani Yuji, Fukunaga Shusei, Otani Koji, Hosomi Shuhei, Kamata Noriko, Nagami Yasuaki, Taira Koichi

机构信息

Department of Gastroenterology, Osaka Metropolitan University.

出版信息

Nihon Shokakibyo Gakkai Zasshi. 2022;119(10):929-936. doi: 10.11405/nisshoshi.119.929.

Abstract

A total of 306 patients with eosinophilic esophagitis (EoE) were analyzed at our department. Proton pump inhibitors or potassium-competitive acid blockers were used as the first-line treatment in 286 (93.5%) patients. Fifty-five (18.0%) patients received topical steroid swallowing therapy. During 17.7-month mean follow-up, 46.4% of the patients were followed-up with no medications, 37.3% of the patients received maintenance or on-demand therapy using acid-suppressive drugs, and 9.8% of the patients received maintenance therapy with steroid swallowing. The majority of patients with EoE were treated using a therapeutic strategy similar to that used for gastroesophageal reflux disease. However, some patients were refractory to the treatment. Current real-world treatment strategies for Japanese patients with EoE are clarified.

摘要

我们科室共分析了306例嗜酸性粒细胞性食管炎(EoE)患者。286例(93.5%)患者使用质子泵抑制剂或钾竞争性酸阻滞剂作为一线治疗。55例(18.0%)患者接受局部类固醇吞咽治疗。在平均17.7个月的随访期间,46.4%的患者在未用药的情况下接受随访,37.3%的患者使用抑酸药物进行维持或按需治疗,9.8%的患者接受类固醇吞咽维持治疗。大多数EoE患者采用了与胃食管反流病相似的治疗策略。然而,一些患者对治疗无效。明确了日本EoE患者目前的实际治疗策略。

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