University of South Florida Morsani College of Medicine, Tampa, Florida, USA.
Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, Florida, USA.
CNS Neurosci Ther. 2023 Jun;29 Suppl 1(Suppl 1):213-219. doi: 10.1111/cns.13988. Epub 2022 Oct 10.
This review focuses on the recent literature regarding the role of the gut-brain axis (GBA) following ischemic stroke.
Stroke is the 5th leading cause of death and disability in the United States; however, few therapies have been developed to improve prognoses. There is a plethora of evidence suggesting peripheral inflammatory responses play a large role in the pathogenesis of stroke. Additionally, hyperglycemic conditions may play a significant role in worsening stroke outcomes due to microbiome dysbiosis.
Recent research has illuminated the vital role of the GBA in propagating poor clinical outcomes, such as hemorrhagic transformation, following ischemic stroke. Considering this detrimental consequence of stroke, and the apparent role of the GBA role, future therapeutics should aim to mitigate this peripheral contribution to stroke complications.
本综述重点关注缺血性卒中后肠-脑轴（Gut-Brain Axis，GBA）的最新文献。
卒中是美国第五大致死和致残原因；然而，仅有少数疗法被开发出来以改善预后。大量证据表明，外周炎症反应在卒中发病机制中起重要作用。此外，高血糖状态可能通过微生物失调导致卒中结局恶化而发挥重要作用。
最近的研究阐明了 GBA 在促进缺血性卒中后不良临床结局（如出血性转化）中的重要作用。鉴于卒中的这种有害后果，以及 GBA 作用的明显作用，未来的治疗方法应旨在减轻这种对外周对卒中并发症的贡献。
Zotero 插件