白细胞介素-6 在创伤性脑损伤和创伤后应激障碍中的作用：一个潜在的治疗靶点？
The role of IL-6 in TBI and PTSD, a potential therapeutic target?
机构信息
University of South Florida Morsani College of Medicine, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, USA.
Department of Neurosurgery and Brain Repair, University of South Florida, Morsani College of Medicine, Tampa, FL, USA.
出版信息
Clin Neurol Neurosurg. 2022 Jul;218:107280. doi: 10.1016/j.clineuro.2022.107280. Epub 2022 May 10.
This literature review focuses on the role of IL-6 in TBI or PTSD-induced neuroinflammation. While TBI and PTSD are widely prevalent, these diagnoses are particularly common amongst veterans. Given the role of IL-6 in neuroprotection acutely, compared to detrimental chronically, targeting this cytokine at specific time points may be beneficial in modulating neuroinflammation. Current treatments for TBI or PTSD are variably affective. By reviewing the role of IL-6 in these two diagnoses, future studies can focus on therapeutics to treat neuroinflammation and ultimately reduce the devastating impacts of neuroinflammation on cognition in PTSD and TBI.
本文献综述重点探讨了白细胞介素 6（IL-6）在创伤性脑损伤（TBI）或创伤后应激障碍（PTSD）引起的神经炎症中的作用。虽然 TBI 和 PTSD 非常普遍，但这些诊断在退伍军人中尤为常见。鉴于白细胞介素 6 在神经保护方面的作用是急性的，而在慢性方面则是有害的，因此在特定时间点靶向这种细胞因子可能有助于调节神经炎症。目前 TBI 或 PTSD 的治疗方法效果各不相同。通过回顾白细胞介素 6 在这两种诊断中的作用，未来的研究可以集中在治疗神经炎症的治疗方法上，最终减轻神经炎症对 PTSD 和 TBI 认知功能的破坏性影响。
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