Research Center, King Fahad Medical City, Riyadh, Saudi Arabia.
Emergency Medicine Department, King Saud University Medical City, Riyadh, Saudi Arabia.
Expert Rev Hematol. 2022 Oct;15(10):893-909. doi: 10.1080/17474086.2022.2132225. Epub 2022 Oct 18.
Evidence related to the national burden of Sickle Cell Disease (SCD) in Gulf Cooperation Council (GCC) largely fragmented. Thus, the aim of this study is to systemically review studies from GCC countries to assess the epidemiological profile of SCD.
We searched combinations of key terms in MEDLINE/PubMed, CINAHL, and EMBASE. We selected relevant observational studies reporting the frequency, incidence, prevalence, risk factors, mortality rate, and complications of SCD among the GCC population. Studies restricted to laboratory diagnostic tests, experimental and animal studies, review articles, case reports and series, and conference proceedings and editorials were excluded. A total of 1,347 articles were retrieved, out of which 98 articles were found to be eligible and included in the study. The total number of participants from all the included studies was 3,496,447. The prevalence of SCD ranged from 0.24%-5.8% across the GCC and from 1.02%-45.8% for the sickle cell trait. Consanguineous marriage was a risk factor for likely giving children affected with hemoglobinopathies.
The prevalence of SCD and its complications vary among GCC. Because of the high prevalence of SCD and its complications, health authorities should focus on more rigorous prevention and treatment strategies.
有关海湾合作委员会（GCC）国家镰状细胞病（SCD）负担的证据大多分散。因此，本研究的目的是系统地审查来自 GCC 国家的研究，以评估 SCD 的流行病学特征。
我们在 MEDLINE/PubMed、CINAHL 和 EMBASE 中搜索了组合关键词。我们选择了报告 GCC 人群中 SCD 的频率、发病率、患病率、危险因素、死亡率和并发症的相关观察性研究。排除仅针对实验室诊断测试、实验和动物研究、综述文章、病例报告和系列以及会议记录和社论的研究。共检索到 1347 篇文章，其中有 98 篇被认为符合条件并纳入研究。所有纳入研究的参与者总数为 3496447 人。GCC 各国的 SCD 患病率从 0.24%-5.8%不等，镰状细胞特征的患病率从 1.02%-45.8%不等。近亲结婚是导致子女患血红蛋白病的一个危险因素。
SCD 及其并发症的患病率在 GCC 之间存在差异。由于 SCD 及其并发症的高患病率，卫生当局应专注于更严格的预防和治疗策略。
