用于增强声动力和化学动力学癌症治疗的树莓状 AgBiS@PVP 纳米粒子。
Raspberry-like AgBiS@PVP nanoparticles for enhanced sonodynamic and chemodynamic cancer therapy.
机构信息
Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, School of Materials Science and Engineering, Hubei University, Wuhan 430062, China.
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出版信息
J Mater Chem B. 2022 Oct 26;10(41):8514-8524. doi: 10.1039/d2tb01645a.
Sonodynamic therapy (SDT) is a non-invasive treatment, preferred by many researchers. Ultrasound is applied to tumor lesions, enriched with a sound sensitizer. The activation of the sound sensitizer produces reactive oxygen species (ROS), which kill the tumor cells. In this study, raspberry-like AgBiS@PVP nanoparticles (NPs) were prepared, which were modified with polyvinylpyrrolidone (PVP). Finally, AgBiS@PVP NPs with 261 nm diameter and a suitable band gap were successfully synthesized. These NPs could play a role in SDT by generating ROS when induced by ultrasonic stimulation. Moreover, the AgBiS@PVP NPs could also catalyze HO in the tumor microenvironment to produce ˙OH, equipping the NPs with chemodynamic therapy (CDT) properties. and experiments suggested that, compared to the single treatments, the combination of SDT and CDT had a clearer inhibitory effect on tumor cells.
声动力学疗法（SDT）是一种非侵入性的治疗方法，受到许多研究人员的青睐。将超声波应用于肿瘤病变部位，并加入声敏剂。声敏剂的激活会产生活性氧物种（ROS），从而杀死肿瘤细胞。在这项研究中，制备了树莓状的 AgBiS@PVP 纳米粒子（NPs），并用聚乙烯吡咯烷酮（PVP）进行了修饰。最后，成功合成了直径为 261nm 且带隙合适的 AgBiS@PVP NPs。这些 NPs 在超声刺激下产生 ROS 时，可以在 SDT 中发挥作用。此外，AgBiS@PVP NPs 还可以在肿瘤微环境中催化 HO 产生˙OH，使 NPs 具有化学动力学治疗（CDT）特性。 和 实验表明，与单一治疗相比，SDT 和 CDT 的联合治疗对肿瘤细胞的抑制作用更明显。
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