Post-graduate Program in Medicine and Health, PPgMS/UFBA-Salvador-BA, Brazil.
Federal University of Bahia-UFBA, Salvador-BA, Brazil.
J Neurol. 2023 Feb;270(2):843-850. doi: 10.1007/s00415-022-11411-5. Epub 2022 Oct 11.
Stroke has a deleterious impact on human health due to its high incidence, degree of disabling sequelae and mortality, constituting one of the main causes of death and disability worldwide.
This study aimed to assess the efficacy and safety of very early mobilization (VEMG) after thrombolysis in functional recovery in patients with acute ischemic stroke.
The present study was an open, prospective, randomized study, with no blinded outcome, carried out in the stroke unit of a tertiary referral hospital located in Salvador-Bahia, Brazil. The primary outcome was the level of functional independence. Secondary outcomes were functional mobility, balance, complications within 7 days of hospitalization and 90 days after hospital discharge, and length of stay.
A total of 104 patients with ischemic stroke who received thrombolytic treatment between August 2020 and July 2021 were prospectively recruited to the study. Of these, 51 patients received VEMG within 24 h of the ictus and another 53 patients receiving usual care (UCG) with mobilization 24 h after the ictus. When compared to the usual care, the VEMG group was not associated with a significant reduction in the risk of the primary outcome (relative risk [95% confidence intervals]: 0.74 [0.339-1.607]) or any of the secondary outcomes.
In this study, the strategy of early mobilization after thrombolysis in ischemic stroke was safe, but without evidence of short-term benefit. Brazilian Registry of Clinical Trials under the registry (registry number: RBR-8bgcs3).
由于发病率高、致残后遗症程度严重和死亡率高，中风对人类健康造成了有害影响，是全球主要死亡和致残原因之一。
本研究旨在评估急性缺血性脑卒中溶栓后早期活动（VEMG）对功能恢复的疗效和安全性。
这是一项在巴西萨尔瓦多-巴伊亚的三级转诊医院卒中单元进行的开放、前瞻性、随机研究，无盲法结局，主要结局是功能独立性水平。次要结局是功能移动性、平衡、住院 7 天内和出院后 90 天内的并发症，以及住院时间。
2020 年 8 月至 2021 年 7 月期间，共有 104 例接受溶栓治疗的缺血性脑卒中患者前瞻性入组本研究。其中，51 例在发病后 24 小时内接受 VEMG，53 例接受常规护理（UCG），在发病后 24 小时内开始活动。与常规护理相比，VEMG 组在主要结局（相对风险[95%置信区间]：0.74[0.339-1.607]）或任何次要结局方面的风险均无显著降低。
在这项研究中，缺血性脑卒中溶栓后早期活动的策略是安全的，但没有短期获益的证据。巴西临床试验注册处（注册号：RBR-8bgcs3）。
