Rayis Duria A, Karar Ahmed, Alshareef Shimos A, Eltayeb Reem, Adam Ishag
Faculty of Medicine, University of Khartoum, P. O. Box 102, Khartoum, Sudan.
Central laboratory, Ministry of Higher Education, PO Box 498, Khartoum, Sudan.
Trans R Soc Trop Med Hyg. 2023 Feb 1;117(2):128-131. doi: 10.1093/trstmh/trac096.
This study was conducted to assess serum levels of folate and vitamin B12 in overweight and obese pregnant women.
A cross-sectional study was conducted at Saad Abualila Hospital, Sudan. Clinical data were collected through questionnaires and body mass index (BMI) was computed from weight and height. The serum folate and vitamin B12 levels were analyzed by immunofluorescence.
Of 300 enrolled women, 44.7% were of normal weight, 32.3% were overweight and 3.0% were obese. The folate level was significantly lower in overweight women (median 4.79 ng/ml [IQR 2.70‒7.70]) than in normal-weight women (median 6.650 ng/ml [IQR 3.30‒10.55]; p=0.022). There was no significant difference in the prevalence of marginal and severe folate deficiencies in women in different BMI groups. Compared with normal-weight women (median 197.5 pg/ml [IQR 150.0‒263.0]), obese women (median 173.0 pg/ml [IQR 150.0‒213.0]; p=0.038) had significantly lower vitamin B12 levels and had a higher prevalence of vitamin B12 insufficiency. Fair negative correlations (p<0.01) were observed between folate and BMI (r = -0.157) and between vitamin B12 and BMI (r = -0.173).
Overweight and obese pregnant Sudanese women had lower levels of serum folate and vitamin B12.
本研究旨在评估超重和肥胖孕妇的血清叶酸和维生素B12水平。
在苏丹的萨阿德·阿布阿利拉医院进行了一项横断面研究。通过问卷调查收集临床数据，并根据体重和身高计算体重指数（BMI）。采用免疫荧光法分析血清叶酸和维生素B12水平。
在300名入选妇女中，44.7%体重正常，32.3%超重，3.0%肥胖。超重妇女的叶酸水平（中位数4.79 ng/ml[四分位间距2.70‒7.70]）显著低于体重正常的妇女（中位数6.650 ng/ml[四分位间距3.30‒10.55]；p=0.022）。不同BMI组妇女边缘性和严重叶酸缺乏的患病率无显著差异。与体重正常的妇女（中位数197.5 pg/ml[四分位间距150.0‒263.0]）相比，肥胖妇女（中位数173.0 pg/ml[四分位间距150.0‒213.0]；p=0.038）的维生素B12水平显著较低，维生素B12不足的患病率较高。叶酸与BMI（r = -0.157）以及维生素B12与BMI（r = -0.173）之间存在显著负相关（p<0.01）。
苏丹超重和肥胖的孕妇血清叶酸和维生素B12水平较低。
