Kusá O, Luknárová O, Riecanský I, Zelenay J
Cor Vasa. 1987;29(3):192-8.
In 120 middle aged male patients with stable angina pectoris and coronarographically documented CAD all examined serum lipid markers differed significantly in comparison with 30 male subjects with vertebro-cardial syndrome and negative coronaro-angiogram (p less than 0.001). The low mean overall coronary score values (4.017 +/- 2.376) reflect the low extent of the coronary atherosclerosis. The coronary score values were significantly positively correlated to the serum levels of cholesterol, triglyceride, LDL-cholesterol, VLDL-cholesterol and negatively correlated to the serum concentration of HDL-cholesterol and HDL-cholesterol/total cholesterol ratios in all examined subjects (CAD and n-CAD groups) (p less than 0.001). In contrast, no significant correlation between coronary score and the examined lipid markers was exhibited in the CAD group of patients when comparing subjects with low and middle coronary score values. According to our results the ratio HDL-cholesterol/total cholesterol represents the best single indicator of the presence and also discriminator of the severity of the coronary athero-sclerosis in the patients with stable angina pectoris.
在120例有稳定型心绞痛且冠状动脉造影证实有冠心病的中年男性患者中，与30例有脊椎 - 心脏综合征且冠状动脉造影阴性的男性受试者相比，所有检测的血清脂质标志物均有显著差异（p < 0.001）。较低的平均总体冠状动脉评分值（4.017 ± 2.376）反映了冠状动脉粥样硬化的程度较低。在所有检测对象（冠心病组和非冠心病组）中，冠状动脉评分值与血清胆固醇、甘油三酯、低密度脂蛋白胆固醇、极低密度脂蛋白胆固醇水平呈显著正相关，与高密度脂蛋白胆固醇血清浓度及高密度脂蛋白胆固醇/总胆固醇比值呈负相关（p < 0.001）。相比之下，在冠心病组患者中，比较低冠状动脉评分值和中等冠状动脉评分值的受试者时，冠状动脉评分与检测的脂质标志物之间未显示出显著相关性。根据我们的结果，高密度脂蛋白胆固醇/总胆固醇比值是稳定型心绞痛患者冠状动脉粥样硬化存在情况的最佳单一指标，也是严重程度的鉴别指标。
