Moolchandani J, Krupin T
Curr Eye Res. 1987 Jul;6(7):935-41. doi: 10.3109/02713688709034862.
Administration of vasoactive intestinal polypeptide (VIP) into the rabbit third ventricle via a permanently placed cannula resulted in a dose-dependent increase in intraocular pressure (IOP). IOP was elevated 5.2 mmHg 30 minutes after VIP (10 micrograms/100 microliter) administration. Tonographic outflow facility was not altered by VIP. Thirty minutes after VIP injection into the third ventricle, aqueous humor flow estimated using the Goldmann equation was increased 36% over baseline levels. Intravenous administration of a 10 micrograms dose of VIP did not alter IOP. Systemic blood pressure was unaltered after third ventricle VIP. Systemic pretreatment with the cholinergic antagonist atropine blocked the VIP-induced elevation in IOP. Topical atropine pretreatment had no effect suggesting a central cholinergic mechanism for the VIP-induced increase in IOP. Physiological antagonism of the VIP response was observed after systemic pretreatment with propranolol, phentolamine, or acetazolamide. Body temperature (BT) was significantly elevated in a dose-dependent manner following central VIP administration. Indomethacin pretreatment which had no effect on the IOP response, blocked the VIP temperature response.
通过永久植入的套管将血管活性肠肽（VIP）注入兔第三脑室，可导致眼内压（IOP）呈剂量依赖性升高。注入VIP（10微克/100微升）30分钟后，眼内压升高了5.2毫米汞柱。VIP未改变眼压描记流出系数。向第三脑室内注入VIP 30分钟后，根据戈德曼方程估算的房水流量比基线水平增加了36%。静脉注射10微克剂量的VIP未改变眼内压。第三脑室注入VIP后，全身血压未改变。用胆碱能拮抗剂阿托品进行全身预处理可阻断VIP诱导的眼内压升高。局部用阿托品预处理无效，提示VIP诱导的眼内压升高存在中枢胆碱能机制。用普萘洛尔、酚妥拉明或乙酰唑胺进行全身预处理后，观察到对VIP反应的生理性拮抗作用。中枢给予VIP后，体温（BT）以剂量依赖性方式显著升高。对眼内压反应无影响的吲哚美辛预处理可阻断VIP的体温反应。
