Instituto Keizo Asami, Universidade Federal de Pernambuco, Recife, Brazil; Núcleo de Ciências da Vida, Centro Acadêmico do Agreste, Universidade Federal de Pernambuco, Caruaru, Brazil; Programa de Pós-Graduação em Biologia Aplicada à Saúde, Universidade Federal de Pernambuco, Recife, Brazil.
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
Biochim Biophys Acta Mol Basis Dis. 2023 Jan 1;1869(1):166565. doi: 10.1016/j.bbadis.2022.166565. Epub 2022 Oct 8.
Immunometabolism has advanced our understanding of how the cellular environment and nutrient availability regulates immune cell fate. Not only are metabolic pathways closely tied to cell signaling and differentiation, but can induce different subsets of immune cells to adopt unique metabolic programs, influencing disease progression. Dysregulation of immune cell metabolism plays an essential role in the progression of several diseases including breast cancer (BC). Metabolic reprogramming plays a critical role in regulating T cell functions. CD8 T cells are an essential cell type within the tumor microenvironment (TME). To induce antitumor responses, CD8 T cells need to adapt their metabolism to fulfill their energy requirement for effective function. However, different markers and immunologic techniques have made identifying specific CD8 T cells subtypes in BC a challenge to the field. This review discusses the immunometabolic processes of CD8 T cell in the TME in the context of BC and highlights the role of CD8 T cell metabolic changes in tumor progression.
免疫代谢学增进了我们对于细胞环境和营养供应如何调节免疫细胞命运的理解。代谢途径不仅与细胞信号转导和分化密切相关，还能诱导免疫细胞的不同亚群采用独特的代谢程序，影响疾病的进展。免疫细胞代谢的失调在包括乳腺癌 (BC) 在内的几种疾病的进展中起着至关重要的作用。代谢重编程在调节 T 细胞功能方面起着关键作用。CD8 T 细胞是肿瘤微环境 (TME) 中的一种重要细胞类型。为了诱导抗肿瘤反应，CD8 T 细胞需要调整其代谢以满足有效功能的能量需求。然而，不同的标记物和免疫技术使得在 BC 中鉴定特定的 CD8 T 细胞亚群成为该领域的一个挑战。本综述讨论了 CD8 T 细胞在 BC 背景下的 TME 中的免疫代谢过程，并强调了 CD8 T 细胞代谢变化在肿瘤进展中的作用。
