Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, USA.
Department of Radiology, College of Medicine-Jacksonville, University of Florida, Jacksonville, FL, USA.
JNCI Cancer Spectr. 2022 Nov 1;6(6). doi: 10.1093/jncics/pkac068.
Adiposity and skeletal muscle levels assessed on computed tomography (CT) scans are prognostic indicators for patients with breast cancer. However, the intraindividual reliability of temporal changes in body composition assessed on opportunistic CT scans is unclear.
This retrospective study included 50 patients newly diagnosed with breast cancer who had archived CT scans pre- and postsurgery for breast cancer. The third lumbar CT image was segmented for areas of 3 types of adipose tissues and 5 different densities of skeletal muscles. Mean and percent changes in areas pre- vs postsurgery were compared using Wilcoxon signed rank tests. Intraclass correlation coefficients (ICCs) with 95% confidence intervals were assessed. A 2-sided P less than .05 was considered statistically significant.
Mean (SD) age at diagnosis was 58.3 (12.5) years, and the interval between CT scans was 590.6 (536.8) days. Areas for body composition components were unchanged except for intermuscular adipose tissue (mean change = 1.45 cm2, 6.74% increase, P = .008) and very high-density muscle (mean change = -0.37 cm2, 11.08% decrease, P = .01) during the interval. There was strong intraindividual reliability in adipose tissue and skeletal muscle areas on pre- vs postsurgery scans overall (ICC = 0.763-0.998) and for scans collected 3 or less years apart (ICC = 0.802-0.999; 42 patients).
Although some body composition components may change after breast cancer surgery, CT scan assessments of body composition were reliable for a 3-year interval including the surgery. These findings inform measurement characteristics of body composition on opportunistic CT scans of patients undergoing surgery for breast cancer.
通过计算机断层扫描（CT）评估的肥胖和骨骼肌水平是乳腺癌患者的预后指标。然而，在机会性 CT 扫描上评估的身体成分的个体内时间变化的可靠性尚不清楚。
本回顾性研究纳入了 50 例新诊断为乳腺癌的患者，这些患者均有乳腺癌术前和术后的 CT 扫描存档。第 3 腰椎 CT 图像用于分割 3 种脂肪组织区域和 5 种不同密度的骨骼肌区域。使用 Wilcoxon 符号秩检验比较术前与术后的面积平均值和百分比变化。使用 95%置信区间评估组内相关系数（ICC）。双侧 P 值小于.05 被认为具有统计学意义。
诊断时的平均（SD）年龄为 58.3（12.5）岁，CT 扫描间隔为 590.6（536.8）天。除肌肉间脂肪组织（平均变化=1.45cm2，增加 6.74%，P=0.008）和极高密度肌肉（平均变化=-0.37cm2，减少 11.08%，P=0.01）外，身体成分成分的面积在间隔期间没有变化。总体而言，术前与术后扫描的脂肪组织和骨骼肌区域的个体内可靠性很强（ICC=0.763-0.998），并且 3 年或更短时间间隔的扫描也是如此（ICC=0.802-0.999；42 例患者）。
尽管乳腺癌手术后某些身体成分可能会发生变化，但 CT 扫描评估身体成分在包括手术在内的 3 年间隔内是可靠的。这些发现为在接受乳腺癌手术的患者的机会性 CT 扫描上进行身体成分测量特征提供了信息。
