Division of Musculoskeletal Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University Hospital, Kanazawa, Japan.
Sci Rep. 2022 Oct 12;12(1):17129. doi: 10.1038/s41598-022-21500-0.
Sarcoma is a rare cancer, and little is known about the etiology, lifestyle epidemiology, and actual circumstances of treatment in hospitals in Japan. Understanding these issues is essential for the effective prevention and treatment of sarcoma. We therefore investigated the incidence of a personal and family cancer history in a total of 1320 sarcoma patients at the National Cancer Center Hospital. In addition, obesity, hypertension, dyslipidemia, diabetes mellitus, drinking, smoking, age and sex were compared in a descriptive study of 1159 of these sarcoma patients who were ≥ 20 years of age, and 7738 controls derived from the National Health and Nutrition Examination Survey in Japan. A total of 8% of sarcoma patients had a personal history of another cancer, and 30% of soft tissue sarcoma patients had a family cancer history in a first-degree relative (malignant peripheral nerve sheath tumor, 52%; leiomyosarcoma, 46%). A smoking habit was associated with the development of sarcoma (odds ratio [OR], 2.05; 95% confidence interval, 1.78-2.37; p < 0.01). According to the histology, the ORs for undifferentiated pleomorphic sarcoma (UPS) of bone, UPS of soft tissue, and liposarcoma were 5.71, 3.04, and 2.92, respectively. A family cancer history may be associated with certain soft tissue sarcomas, and a smoking habit was significantly associated with the development of sarcomas; however, further studies are necessary.
肉瘤是一种罕见的癌症，关于其病因、生活方式流行病学以及日本医院的实际治疗情况知之甚少。了解这些问题对于肉瘤的有效预防和治疗至关重要。因此，我们调查了国立癌症中心医院 1320 名肉瘤患者的个人和家族癌症史。此外，我们对年龄≥20 岁的 1159 名肉瘤患者和日本全国健康和营养调查的 7738 名对照者进行了描述性研究，比较了肥胖、高血压、血脂异常、糖尿病、饮酒、吸烟、年龄和性别。8%的肉瘤患者有另一种癌症的个人病史，30%的软组织肉瘤患者有一级亲属的家族癌症史（恶性外周神经鞘瘤，52%；平滑肌肉瘤，46%）。吸烟习惯与肉瘤的发生有关（比值比[OR]，2.05；95%置信区间，1.78-2.37；p<0.01）。根据组织学，骨未分化多形性肉瘤（UPS）、软组织 UPS 和脂肪肉瘤的 OR 分别为 5.71、3.04 和 2.92。家族癌症史可能与某些软组织肉瘤有关，吸烟习惯与肉瘤的发生显著相关；然而，还需要进一步的研究。
