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Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline.非结核分枝杆菌肺病治疗:美国胸科学会/欧洲呼吸学会/欧洲临床微生物学和传染病学会/美国感染病学会临床实践指南。
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2
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Eur Respir J. 2020 Jul 7;56(1). doi: 10.1183/13993003.00535-2020. Print 2020 Jul.
3
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BMC Microbiol. 2020 Jun 12;20(1):158. doi: 10.1186/s12866-020-01840-5.
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[Clinical Epidemiological Characteristics of Newly Reported HIV/AIDS in a Certain General Hospital from 2001 to 2017].[某综合医院2001年至2017年新报告艾滋病病毒/艾滋病临床流行病学特征]
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[2016 - 2021年中国四川非结核分枝杆菌感染病例的临床特征:一项回顾性研究]

[Clinical Characteristics of Nontuberculous Mycobacterium Infection Cases in Sichuan, China in 2016-2021: A Retrospective Study].

作者信息

Luo Jia, Yu Qiu-Ju, Lin Yu-Ling, Yi Fan-Li, Xiong Li, Xie Yi

机构信息

Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.

The Public Health Clinical Center of Chengdu, Chengdu 610066, China.

出版信息

Sichuan Da Xue Xue Bao Yi Xue Ban. 2022 Sep;53(5):890-895. doi: 10.12182/20220960503.

DOI:10.12182/20220960503
PMID:36224693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10408787/
Abstract

OBJECTIVE

To study the distribution of nontuberculous mycobacterium (NTM) strains, clinical characteristics and drug sensitivity data of NTM infections so as to provide support for the prevention and treatment of diseases caused by NTM infection in Sichuan.

METHODS

The clinical data of NTM infection cases treated at the Public Health Clinical Center of Chengdu between July 2016 and July 2021 were collected and the characteristics of the infections were retrospectively reviewed.

RESULTS

There were differences in sex, age and underlying diseases among the NTM infection cases in Sichuan. Specifically, young and middle-aged men aged between 20 and 40 were susceptible to AIDS, older men aged over 60 were susceptible to lung diseases, and middle-aged and older women over 40 were susceptible to bronchiectasis. Respiratory tract was the main route of NTM infection. The dominant strain in Sichuan was / . The drug resistance rate of and / were relatively higher.

CONCLUSION

For NTM infection patients with different demographic characteristics and underlying diseases, the NTM infection sites, strains, and drug resistance are also different. Definite etiological diagnosis is essential to the treatment of NTM infection. We should highlight the importance of adopting individualized treatment for different NTM infections.

摘要

目的

研究非结核分枝杆菌(NTM)菌株分布、NTM感染的临床特征及药敏数据,为四川省NTM感染所致疾病的防治提供依据。

方法

收集2016年7月至2021年7月在成都市公共卫生临床中心治疗的NTM感染病例的临床资料,并对感染特征进行回顾性分析。

结果

四川省NTM感染病例在性别、年龄及基础疾病方面存在差异。具体而言,20至40岁的中青年男性易患艾滋病,60岁以上的老年男性易患肺部疾病,40岁以上的中老年女性易患支气管扩张症。呼吸道是NTM感染的主要途径。四川省的优势菌株为/ 。/ 及/ 的耐药率相对较高。

结论

对于具有不同人口学特征及基础疾病的NTM感染患者,NTM感染部位、菌株及耐药情况也存在差异。明确的病原学诊断对NTM感染的治疗至关重要。应重视针对不同NTM感染采取个体化治疗。